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Obesity and the microvasculature: a systematic review and meta-analysis.

Publication ,  Journal Article
Boillot, A; Zoungas, S; Mitchell, P; Klein, R; Klein, B; Ikram, MK; Klaver, C; Wang, JJ; Gopinath, B; Tai, ES; Neubauer, AS; Hercberg, S ...
Published in: PLoS One
2013

BACKGROUND: Overweight and obesity are thought to significantly influence a person's risk of cardiovascular disease, possibly via its effect on the microvasculature. Retinal vascular caliber is a surrogate marker of microvascular disease and a predictor of cardiovascular events. The aim of this systematic review and meta-analysis was to determine the association between body mass index (BMI) and retinal vascular caliber. METHODS AND FINDINGS: Relevant studies were identified by searches of the MEDLINE and EMBASE databases from 1966 to August 2011. Standardized forms were used for data extraction. Among over 44,000 individuals, obese subjects had narrower arteriolar and wider venular calibers when compared with normal weight subjects, independent of conventional cardiovascular risk factors. In adults, a 1 kg/m(2) increase in BMI was associated with a difference of 0.07 μm [95% CI: -0.08; -0.06] in arteriolar caliber and 0.22 μm [95% CI: 0.21; 0.23] in venular caliber. Similar results were found for children. CONCLUSIONS: Higher BMI is associated with narrower retinal arteriolar and wider venular calibers. Further prospective studies are needed to examine whether a causative relationship between BMI and retinal microcirculation exists.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

2

Start / End Page

e52708

Location

United States

Related Subject Headings

  • Risk Factors
  • Retinal Vessels
  • Obesity
  • Middle Aged
  • Microvessels
  • Humans
  • General Science & Technology
  • Child
  • Body Mass Index
  • Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Boillot, A., Zoungas, S., Mitchell, P., Klein, R., Klein, B., Ikram, M. K., … META-EYE Study Group, . (2013). Obesity and the microvasculature: a systematic review and meta-analysis. PLoS One, 8(2), e52708. https://doi.org/10.1371/journal.pone.0052708
Boillot, Adrien, Sophia Zoungas, Paul Mitchell, Ronald Klein, Barbara Klein, Mohammad Kamran Ikram, Caroline Klaver, et al. “Obesity and the microvasculature: a systematic review and meta-analysis.PLoS One 8, no. 2 (2013): e52708. https://doi.org/10.1371/journal.pone.0052708.
Boillot A, Zoungas S, Mitchell P, Klein R, Klein B, Ikram MK, et al. Obesity and the microvasculature: a systematic review and meta-analysis. PLoS One. 2013;8(2):e52708.
Boillot, Adrien, et al. “Obesity and the microvasculature: a systematic review and meta-analysis.PLoS One, vol. 8, no. 2, 2013, p. e52708. Pubmed, doi:10.1371/journal.pone.0052708.
Boillot A, Zoungas S, Mitchell P, Klein R, Klein B, Ikram MK, Klaver C, Wang JJ, Gopinath B, Tai ES, Neubauer AS, Hercberg S, Brazionis L, Saw S-M, Wong T-Y, Czernichow S, META-EYE Study Group. Obesity and the microvasculature: a systematic review and meta-analysis. PLoS One. 2013;8(2):e52708.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

2

Start / End Page

e52708

Location

United States

Related Subject Headings

  • Risk Factors
  • Retinal Vessels
  • Obesity
  • Middle Aged
  • Microvessels
  • Humans
  • General Science & Technology
  • Child
  • Body Mass Index
  • Aged