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The relationship between retinal vessel calibre and knee cartilage and BMLs.

Publication ,  Journal Article
Davies-Tuck, ML; Kawasaki, R; Wluka, AE; Wong, TY; Hodgson, L; English, DR; Giles, GG; Cicuttini, F
Published in: BMC Musculoskelet Disord
December 20, 2012

BACKGROUND: Whether the increase in vascular disease prevalence and mortality in OA populations is a result of co-occurrence of cardiovascular disease and OA, which are both common in the older population, is due to OA treatments or to the common association with reduced physical activity and/or obesity is unclear. One way to explore this non-invasively is to examine the cross-sectional relationship between changes in retinal microvasculature, which have been shown to be markers of generalized vascular pathology, and knee structural changes in an asymptomatic community-based population. METHODS: A community sample of 289 (61% women) aged 50-79 years with no knee symptoms underwent magnetic resonance imaging (MRI) of their dominant knee in 2003. Cartilage volume and bone marrow lesions (BMLs) were determined. All subjects also had retinal photographs taken from which retinal arteriolar and venular diameters were determined and summarized as the central retinal arteriolar equivalent (CRAE) and the central retinal venular equivalent (CRVE). RESULTS: Retinal venular diameter was significantly wider in subjects with a BML compared with subjects without a BML (mean (SD) 214.2 (2.8) μm versus 207.5 (1.1) μm respectively independent of age, gender and BMI. A trend for decreased medial tibial cartilage with increasing CRAE was also observed (regression coefficient -2.70 μl, 95%CI-5.74, 0.5, p=0.08). CONCLUSION: These findings suggest that vascular pathology, indicative of inflammatory processes, is associated with early structural knee changes. The role of micro-vascular changes in the pathogenesis of OA warrants further investigation.

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Published In

BMC Musculoskelet Disord

DOI

EISSN

1471-2474

Publication Date

December 20, 2012

Volume

13

Start / End Page

255

Location

England

Related Subject Headings

  • Venules
  • Retinal Vessels
  • Retinal Vasculitis
  • Predictive Value of Tests
  • Osteoarthritis, Knee
  • Orthopedics
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Linear Models
 

Citation

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ICMJE
MLA
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Davies-Tuck, M. L., Kawasaki, R., Wluka, A. E., Wong, T. Y., Hodgson, L., English, D. R., … Cicuttini, F. (2012). The relationship between retinal vessel calibre and knee cartilage and BMLs. BMC Musculoskelet Disord, 13, 255. https://doi.org/10.1186/1471-2474-13-255
Davies-Tuck, Miranda L., Ryo Kawasaki, Anita E. Wluka, Tien Y. Wong, Lauren Hodgson, Dallas R. English, Graham G. Giles, and Flavia Cicuttini. “The relationship between retinal vessel calibre and knee cartilage and BMLs.BMC Musculoskelet Disord 13 (December 20, 2012): 255. https://doi.org/10.1186/1471-2474-13-255.
Davies-Tuck ML, Kawasaki R, Wluka AE, Wong TY, Hodgson L, English DR, et al. The relationship between retinal vessel calibre and knee cartilage and BMLs. BMC Musculoskelet Disord. 2012 Dec 20;13:255.
Davies-Tuck, Miranda L., et al. “The relationship between retinal vessel calibre and knee cartilage and BMLs.BMC Musculoskelet Disord, vol. 13, Dec. 2012, p. 255. Pubmed, doi:10.1186/1471-2474-13-255.
Davies-Tuck ML, Kawasaki R, Wluka AE, Wong TY, Hodgson L, English DR, Giles GG, Cicuttini F. The relationship between retinal vessel calibre and knee cartilage and BMLs. BMC Musculoskelet Disord. 2012 Dec 20;13:255.
Journal cover image

Published In

BMC Musculoskelet Disord

DOI

EISSN

1471-2474

Publication Date

December 20, 2012

Volume

13

Start / End Page

255

Location

England

Related Subject Headings

  • Venules
  • Retinal Vessels
  • Retinal Vasculitis
  • Predictive Value of Tests
  • Osteoarthritis, Knee
  • Orthopedics
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Linear Models