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Relationship of blood pressure and other factors to serial retinal arteriolar diameter measurements over time: the beaver dam eye study.

Publication ,  Journal Article
Klein, R; Myers, CE; Knudtson, MD; Lee, KE; Gangnon, R; Wong, TY; Klein, BEK
Published in: Arch Ophthalmol
August 2012

OBJECTIVE: To describe the relationship of blood pressure (BP), antihypertensive medication use, and other factors to serial measurements of retinal arteriolar diameters over time in the Beaver Dam Eye Study. METHODS: Retinal arteriolar diameter was measured by computer-assisted methods and summarized as central retinal arteriolar equivalent (CRAE) in 4573 persons aged 43 to 99 years at 4 examinations (each separated by 5 years) during a 15-year period. Associations of CRAE with risk factors measured concurrently and 5 years previously were determined using multivariate analyses. RESULTS: While adjusting for image quality, refraction, and lens status, age (per 10 years: β estimate, -0.73; P < .001), systolic BP (per 10 mm Hg: concurrent examination, -2.74; P < .001; previous examination, -1.75; P < .001), smoking status (smoker vs nonsmoker: concurrent examination, 4.29; P < .001; previous examination, 1.63; P = .004), body mass index (per category: concurrent examination, -0.51; P = .05; previous examination, -0.22; P = .44), and heavy alcohol consumption (drinking) (current vs past/never heavy drinker: concurrent examination, -2.54; P = .03; previous examination, -2.42; P = .02) were associated with CRAE. In the same model, there were significant interactions between concurrent and previous systolic BP (0.11; P = .003) and between concurrent and previous body mass index (0.12; P = .04). Use of calcium channel blockers at both the concurrent and past examination (vs neither examination, 1.59; P = .01), but not other classes of antihypertensive drugs, was associated with CRAE. CONCLUSIONS: Retinal arteriolar diameter is independently associated with past and current systolic BP, calcium channel blocker use, smoking status, body mass index, and heavy drinking during 5-year intervals. The relationships with CRAE are stronger for concurrent than for past measures of these variables.

Duke Scholars

Published In

Arch Ophthalmol

DOI

EISSN

1538-3601

Publication Date

August 2012

Volume

130

Issue

8

Start / End Page

1019 / 1027

Location

United States

Related Subject Headings

  • Wisconsin
  • Smoking
  • Risk Factors
  • Retinal Artery
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Humans
  • Female
  • Calcium Channel Blockers
 

Citation

APA
Chicago
ICMJE
MLA
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Klein, R., Myers, C. E., Knudtson, M. D., Lee, K. E., Gangnon, R., Wong, T. Y., & Klein, B. E. K. (2012). Relationship of blood pressure and other factors to serial retinal arteriolar diameter measurements over time: the beaver dam eye study. Arch Ophthalmol, 130(8), 1019–1027. https://doi.org/10.1001/archophthalmol.2012.560
Klein, Ronald, Chelsea E. Myers, Michael D. Knudtson, Kristine E. Lee, Ronald Gangnon, Tien Y. Wong, and Barbara E. K. Klein. “Relationship of blood pressure and other factors to serial retinal arteriolar diameter measurements over time: the beaver dam eye study.Arch Ophthalmol 130, no. 8 (August 2012): 1019–27. https://doi.org/10.1001/archophthalmol.2012.560.
Klein R, Myers CE, Knudtson MD, Lee KE, Gangnon R, Wong TY, et al. Relationship of blood pressure and other factors to serial retinal arteriolar diameter measurements over time: the beaver dam eye study. Arch Ophthalmol. 2012 Aug;130(8):1019–27.
Klein, Ronald, et al. “Relationship of blood pressure and other factors to serial retinal arteriolar diameter measurements over time: the beaver dam eye study.Arch Ophthalmol, vol. 130, no. 8, Aug. 2012, pp. 1019–27. Pubmed, doi:10.1001/archophthalmol.2012.560.
Klein R, Myers CE, Knudtson MD, Lee KE, Gangnon R, Wong TY, Klein BEK. Relationship of blood pressure and other factors to serial retinal arteriolar diameter measurements over time: the beaver dam eye study. Arch Ophthalmol. 2012 Aug;130(8):1019–1027.

Published In

Arch Ophthalmol

DOI

EISSN

1538-3601

Publication Date

August 2012

Volume

130

Issue

8

Start / End Page

1019 / 1027

Location

United States

Related Subject Headings

  • Wisconsin
  • Smoking
  • Risk Factors
  • Retinal Artery
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Humans
  • Female
  • Calcium Channel Blockers