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Age-related macular degeneration and long-term risk of stroke subtypes.

Publication ,  Journal Article
Ikram, MK; Mitchell, P; Klein, R; Sharrett, AR; Couper, DJ; Wong, TY
Published in: Stroke
June 2012

BACKGROUND AND PURPOSE: We examined the relationship of age-related macular degeneration (AMD) with incident stroke, including stroke subtypes of cerebral infarction and intracerebral hemorrhage. METHODS: We included 12 216 participants with retinal photographs taken at the third examination visit (1993-1995) from the Atherosclerosis Risk in Communities (ARIC) Study, a population-based cohort study in middle-aged persons. Images were evaluated for AMD signs according to a standardized protocol. Incident events of stroke and its subtypes were identified and validated through case record review over time. RESULTS: AMD was diagnosed in 591 participants, of whom 576 had early and 15 late AMD. After a mean follow-up of 13.0 years (SD, 3.3), 619 persons developed an incident stroke, including 548 cerebral infarction and 57 intracerebral hemorrhages. Participants with any AMD were at an increased risk of stroke (multivariable adjusted hazard ratio, 1.51; 95% CI, 1.11-2.06) with a stronger association for intracerebral hemorrhage (hazard ratio, 2.64; 95% CI, 1.18-5.87) than cerebral infarction (hazard ratio, 1.42; 95% CI, 1.01-1.99). CONCLUSIONS: Persons with AMD are at an increased risk of both cerebral infarction and intracerebral hemorrhage. These data provide further insight into common pathophysiological processes between AMD and stroke subtypes.

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Published In

Stroke

DOI

EISSN

1524-4628

Publication Date

June 2012

Volume

43

Issue

6

Start / End Page

1681 / 1683

Location

United States

Related Subject Headings

  • Time Factors
  • Stroke
  • Risk Factors
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Macular Degeneration
  • Incidence
  • Humans
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ikram, M. K., Mitchell, P., Klein, R., Sharrett, A. R., Couper, D. J., & Wong, T. Y. (2012). Age-related macular degeneration and long-term risk of stroke subtypes. Stroke, 43(6), 1681–1683. https://doi.org/10.1161/STROKEAHA.112.654632
Ikram, M Kamran, Paul Mitchell, Ronald Klein, A Rickey Sharrett, David J. Couper, and Tien Y. Wong. “Age-related macular degeneration and long-term risk of stroke subtypes.Stroke 43, no. 6 (June 2012): 1681–83. https://doi.org/10.1161/STROKEAHA.112.654632.
Ikram MK, Mitchell P, Klein R, Sharrett AR, Couper DJ, Wong TY. Age-related macular degeneration and long-term risk of stroke subtypes. Stroke. 2012 Jun;43(6):1681–3.
Ikram, M. Kamran, et al. “Age-related macular degeneration and long-term risk of stroke subtypes.Stroke, vol. 43, no. 6, June 2012, pp. 1681–83. Pubmed, doi:10.1161/STROKEAHA.112.654632.
Ikram MK, Mitchell P, Klein R, Sharrett AR, Couper DJ, Wong TY. Age-related macular degeneration and long-term risk of stroke subtypes. Stroke. 2012 Jun;43(6):1681–1683.

Published In

Stroke

DOI

EISSN

1524-4628

Publication Date

June 2012

Volume

43

Issue

6

Start / End Page

1681 / 1683

Location

United States

Related Subject Headings

  • Time Factors
  • Stroke
  • Risk Factors
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Macular Degeneration
  • Incidence
  • Humans
  • Follow-Up Studies