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Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the singapore malay eye study.

Publication ,  Journal Article
Zheng, Y; Cheung, N; Aung, T; Mitchell, P; He, M; Wong, TY
Published in: Invest Ophthalmol Vis Sci
September 2009

PURPOSE: To describe the relationship of retinal arteriolar and venular caliber with retinal nerve fiber layer (RNFL) thickness. METHODS: A population-based, cross-sectional study of Malay persons aged 40 to 80 years residing in Singapore was conducted from 2004 to 2006. Retinal arteriolar and venular calibers were measured with a computer-based technique according to a validated, standardized protocol. RNFL was assessed with retinal tomography. RESULTS: There were 2706 persons with gradable retinal photographs and HRT images of acceptable quality available for analysis. In linear regression models that adjusted for age, sex, diabetes, body mass index, intraocular pressure, and other factors, each standard deviation decrease in arteriolar and venular caliber was associated with a 5.81- and 8.37-microm decrease, respectively, in mean global RNFL thickness (both P < 0.001). These associations remained similar after persons with glaucoma were excluded. In persons with glaucoma, retinal venular caliber was independently associated with the temporal and temporal-to-inferior region of mean RNFL thickness in multivariate analysis; each SD decrease in retinal venular diameter was associated with an 8.54-microm decrease in the temporal region (P = 0.022), and a 38.32-microm decrease in the temporal-to-inferior region (P = 0.006) of mean RNFL thickness. CONCLUSIONS: Narrower retinal vessel caliber was associated with reduced RNFL thickness in this Asian population.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

September 2009

Volume

50

Issue

9

Start / End Page

4091 / 4096

Location

United States

Related Subject Headings

  • Venules
  • Singapore
  • Retinal Vessels
  • Retinal Ganglion Cells
  • Photography
  • Optic Nerve Diseases
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zheng, Y., Cheung, N., Aung, T., Mitchell, P., He, M., & Wong, T. Y. (2009). Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the singapore malay eye study. Invest Ophthalmol Vis Sci, 50(9), 4091–4096. https://doi.org/10.1167/iovs.09-3444
Zheng, Yingfeng, Ning Cheung, Tin Aung, Paul Mitchell, Mingguang He, and Tien Y. Wong. “Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the singapore malay eye study.Invest Ophthalmol Vis Sci 50, no. 9 (September 2009): 4091–96. https://doi.org/10.1167/iovs.09-3444.
Zheng Y, Cheung N, Aung T, Mitchell P, He M, Wong TY. Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the singapore malay eye study. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4091–6.
Zheng, Yingfeng, et al. “Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the singapore malay eye study.Invest Ophthalmol Vis Sci, vol. 50, no. 9, Sept. 2009, pp. 4091–96. Pubmed, doi:10.1167/iovs.09-3444.
Zheng Y, Cheung N, Aung T, Mitchell P, He M, Wong TY. Relationship of retinal vascular caliber with retinal nerve fiber layer thickness: the singapore malay eye study. Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4091–4096.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

September 2009

Volume

50

Issue

9

Start / End Page

4091 / 4096

Location

United States

Related Subject Headings

  • Venules
  • Singapore
  • Retinal Vessels
  • Retinal Ganglion Cells
  • Photography
  • Optic Nerve Diseases
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Middle Aged
  • Male