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Serum apolipoprotein AI and B are stronger biomarkers of diabetic retinopathy than traditional lipids.

Publication ,  Journal Article
Sasongko, MB; Wong, TY; Nguyen, TT; Kawasaki, R; Jenkins, A; Shaw, J; Wang, JJ
Published in: Diabetes Care
February 2011

OBJECTIVE: To describe and compare the associations of serum lipoproteins and apolipoproteins with diabetic retinopathy. RESEARCH DESIGN AND METHODS: This was a cross-sectional study of 224 diabetic patients (85 type 1 and 139 type 2) from a diabetes clinic. Diabetic retinopathy was graded from fundus photographs according to the Airlie House Classification system and categorized into mild, moderate, and vision-threatening diabetic retinopathy (VTDR). Serum traditional lipids (total, LDL, non-HDL, and HDL cholesterol and triglycerides) and apolipoprotein AI (apoAI), apolipoprotein B (apoB), and the apoB-to-apoAI ratio were assessed. RESULTS: Diabetic retinopathy was present in 133 (59.4%) individuals. After adjustment for age, sex, diabetes duration, A1C, systolic blood pressure, and diabetes medications, the HDL cholesterol level was inversely associated with diabetic retinopathy (odds ratio 0.39 [95% CI 0.16-0.94], highest versus lowest quartile; P(trend) = 0.017). The ApoAI level was inversely associated with diabetic retinopathy (per SD increase, 0.76 [95% CI 0.59-0.98]), whereas apoB (per SD increase, 1.31 [1.02-1.68]) and the apoB-to-apoAI ratio (per SD increase, 1.48 [1.13-1.95]) were positively associated with diabetic retinopathy. Results were similar for mild to moderate diabetic retinopathy and VTDR. Traditional lipid levels improved the area under the receiver operating curve by 1.8%, whereas apolipoproteins improved the area by 8.2%. CONCLUSIONS: ApoAI and apoB and the apoB-to-apoAI ratio were significantly and independently associated with diabetic retinopathy and diabetic retinopathy severity and improved the ability to discriminate diabetic retinopathy by 8%. Serum apolipoprotein levels may therefore be stronger biomarkers of diabetic retinopathy than traditional lipid measures.

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Published In

Diabetes Care

DOI

EISSN

1935-5548

Publication Date

February 2011

Volume

34

Issue

2

Start / End Page

474 / 479

Location

United States

Related Subject Headings

  • Young Adult
  • Triglycerides
  • Severity of Illness Index
  • Risk Factors
  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Humans
  • Female
  • Endocrinology & Metabolism
 

Citation

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Sasongko, M. B., Wong, T. Y., Nguyen, T. T., Kawasaki, R., Jenkins, A., Shaw, J., & Wang, J. J. (2011). Serum apolipoprotein AI and B are stronger biomarkers of diabetic retinopathy than traditional lipids. Diabetes Care, 34(2), 474–479. https://doi.org/10.2337/dc10-0793
Sasongko, Muhammad Bayu, Tien Y. Wong, Thanh T. Nguyen, Ryo Kawasaki, Alicia Jenkins, Jonathan Shaw, and Jie Jin Wang. “Serum apolipoprotein AI and B are stronger biomarkers of diabetic retinopathy than traditional lipids.Diabetes Care 34, no. 2 (February 2011): 474–79. https://doi.org/10.2337/dc10-0793.
Sasongko MB, Wong TY, Nguyen TT, Kawasaki R, Jenkins A, Shaw J, et al. Serum apolipoprotein AI and B are stronger biomarkers of diabetic retinopathy than traditional lipids. Diabetes Care. 2011 Feb;34(2):474–9.
Sasongko, Muhammad Bayu, et al. “Serum apolipoprotein AI and B are stronger biomarkers of diabetic retinopathy than traditional lipids.Diabetes Care, vol. 34, no. 2, Feb. 2011, pp. 474–79. Pubmed, doi:10.2337/dc10-0793.
Sasongko MB, Wong TY, Nguyen TT, Kawasaki R, Jenkins A, Shaw J, Wang JJ. Serum apolipoprotein AI and B are stronger biomarkers of diabetic retinopathy than traditional lipids. Diabetes Care. 2011 Feb;34(2):474–479.

Published In

Diabetes Care

DOI

EISSN

1935-5548

Publication Date

February 2011

Volume

34

Issue

2

Start / End Page

474 / 479

Location

United States

Related Subject Headings

  • Young Adult
  • Triglycerides
  • Severity of Illness Index
  • Risk Factors
  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Humans
  • Female
  • Endocrinology & Metabolism