Skip to main content

Retinal venular caliber predicts visual outcome after intravitreal ranibizumab injection treatments for neovascular AMD.

Publication ,  Journal Article
Wickremasinghe, SS; Busija, L; Guymer, RH; Wong, TY; Qureshi, S
Published in: Invest Ophthalmol Vis Sci
January 3, 2012

PURPOSE: To examine whether baseline retinal vascular caliber predicts visual response to intravitreal ranibizumab injections in patients with neovascular age-related macular degeneration (AMD). METHODS: In this prospective cohort study, patients with neovascular AMD received three monthly intravitreal injections of ranibizumab, followed by as needed dosing up to 1 year. Retinal vascular caliber was measured from digital fundus photographs at baseline and summarized as central retinal artery equivalent (CRAE) and venular equivalent (CRVE), representing average caliber of arterioles and venules, respectively. Visual outcome at 12 months was assessed and the relation to baseline retinal vascular caliber was determined. RESULTS: A total of 88 eyes were analyzed at baseline. After accounting for age, sex, size of choroidal neovascularization, and number of injections, patients who deteriorated in visual acuity at 12 months had significantly larger baseline CRVE, 243.10 μm (95% confidence interval [CI], 227.01-259.19), compared with those who were stable, 214.30 μm (95% CI, 205.79-222.81) and those who improved, 215.26 μm (95% CI, 204.69-225.84; P = 0.007). Baseline CRAE did not differ significantly from eyes whose vision deteriorated, 150.12 μm (95% CI, 140.67-159.57), compared with those remaining stable, 143.64 μm (95% CI, 138.64-148.63), or gaining vision 142.92 μm (95% CI, 136.71-149.13; P = 0.69). CONCLUSIONS: In eyes with neovascular AMD treated with intravitreal ranibizumab, larger baseline retinal venular caliber was significantly associated with a poorer response to treatment, possibly reflecting increased disease severity.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

January 3, 2012

Volume

53

Issue

1

Start / End Page

37 / 41

Location

United States

Related Subject Headings

  • Wet Macular Degeneration
  • Visual Acuity
  • Treatment Outcome
  • Tomography, Optical Coherence
  • Retinal Vein
  • Ranibizumab
  • Prospective Studies
  • Photography
  • Ophthalmology & Optometry
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wickremasinghe, S. S., Busija, L., Guymer, R. H., Wong, T. Y., & Qureshi, S. (2012). Retinal venular caliber predicts visual outcome after intravitreal ranibizumab injection treatments for neovascular AMD. Invest Ophthalmol Vis Sci, 53(1), 37–41. https://doi.org/10.1167/iovs.11-7689
Wickremasinghe, Sanjeewa S., Lucy Busija, Robyn H. Guymer, Tien Y. Wong, and Salmaan Qureshi. “Retinal venular caliber predicts visual outcome after intravitreal ranibizumab injection treatments for neovascular AMD.Invest Ophthalmol Vis Sci 53, no. 1 (January 3, 2012): 37–41. https://doi.org/10.1167/iovs.11-7689.
Wickremasinghe SS, Busija L, Guymer RH, Wong TY, Qureshi S. Retinal venular caliber predicts visual outcome after intravitreal ranibizumab injection treatments for neovascular AMD. Invest Ophthalmol Vis Sci. 2012 Jan 3;53(1):37–41.
Wickremasinghe, Sanjeewa S., et al. “Retinal venular caliber predicts visual outcome after intravitreal ranibizumab injection treatments for neovascular AMD.Invest Ophthalmol Vis Sci, vol. 53, no. 1, Jan. 2012, pp. 37–41. Pubmed, doi:10.1167/iovs.11-7689.
Wickremasinghe SS, Busija L, Guymer RH, Wong TY, Qureshi S. Retinal venular caliber predicts visual outcome after intravitreal ranibizumab injection treatments for neovascular AMD. Invest Ophthalmol Vis Sci. 2012 Jan 3;53(1):37–41.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

January 3, 2012

Volume

53

Issue

1

Start / End Page

37 / 41

Location

United States

Related Subject Headings

  • Wet Macular Degeneration
  • Visual Acuity
  • Treatment Outcome
  • Tomography, Optical Coherence
  • Retinal Vein
  • Ranibizumab
  • Prospective Studies
  • Photography
  • Ophthalmology & Optometry
  • Male