Skip to main content

Metabolic syndrome components and age-related cataract: the Singapore Malay eye study.

Publication ,  Journal Article
Sabanayagam, C; Wang, JJ; Mitchell, P; Tan, AG; Tai, ES; Aung, T; Saw, S-M; Wong, TY
Published in: Invest Ophthalmol Vis Sci
April 14, 2011

PURPOSE: To examine the relationship between metabolic syndrome and its components, diabetes mellitus, high blood pressure (BP), obesity, and dyslipidemia, with age-related cataract. METHODS: A population-based sample of 2794 Malay adults aged 40 to 80 years in Singapore was used for this analysis. Cataract (n = 1268) was defined as the presence of nuclear, cortical, or posterior subcapsular (PSC) cataract, from standardized grading of lens photographs or previous cataract surgery. Metabolic syndrome was defined as the presence of ≥ 3 of the following components: body mass index (BMI) ≥ 25 kg/m(2), triglycerides ≥ 1.7 mM, high density-lipoprotein (HDL) cholesterol <1.0 mM in men and <1.3 mM in women, BP ≥ 130/85 mm Hg, or use of BP medication and diabetes mellitus. RESULTS: Cataract prevalence increased with higher quartiles of blood glucose, systolic BP, and metabolic syndrome components (P trend < 0.0001). The multivariable odds ratio (OR) (95% confidence interval [CI]) of cataract was 1.89 (1.42-2.40) for diabetes, 1.92 (1.47-2.52) for high BP, and 1.27 (1.04-1.55) for metabolic syndrome. Of the individual metabolic syndrome components, high BP was associated with all three cataract types; diabetes was associated with cortical and PSC; low HDL, high BMI, and metabolic syndrome were associated with cortical cataract. The presence of both high BP and diabetes was associated with fourfold odds of having cataract (OR [95% CI] = 4.73 [2.16-10.34]). CONCLUSIONS: Metabolic syndrome and its two key components, high BP and diabetes were associated with age-related cataract.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

April 14, 2011

Volume

52

Issue

5

Start / End Page

2397 / 2404

Location

United States

Related Subject Headings

  • Triglycerides
  • Singapore
  • Risk Factors
  • Prevalence
  • Ophthalmology & Optometry
  • Obesity
  • Middle Aged
  • Metabolic Syndrome
  • Male
  • Hypertension
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sabanayagam, C., Wang, J. J., Mitchell, P., Tan, A. G., Tai, E. S., Aung, T., … Wong, T. Y. (2011). Metabolic syndrome components and age-related cataract: the Singapore Malay eye study. Invest Ophthalmol Vis Sci, 52(5), 2397–2404. https://doi.org/10.1167/iovs.10-6373
Sabanayagam, Charumathi, Jie Jin Wang, Paul Mitchell, Ava Grace Tan, E Shyong Tai, Tin Aung, Seang-Mei Saw, and Tien Yin Wong. “Metabolic syndrome components and age-related cataract: the Singapore Malay eye study.Invest Ophthalmol Vis Sci 52, no. 5 (April 14, 2011): 2397–2404. https://doi.org/10.1167/iovs.10-6373.
Sabanayagam C, Wang JJ, Mitchell P, Tan AG, Tai ES, Aung T, et al. Metabolic syndrome components and age-related cataract: the Singapore Malay eye study. Invest Ophthalmol Vis Sci. 2011 Apr 14;52(5):2397–404.
Sabanayagam, Charumathi, et al. “Metabolic syndrome components and age-related cataract: the Singapore Malay eye study.Invest Ophthalmol Vis Sci, vol. 52, no. 5, Apr. 2011, pp. 2397–404. Pubmed, doi:10.1167/iovs.10-6373.
Sabanayagam C, Wang JJ, Mitchell P, Tan AG, Tai ES, Aung T, Saw S-M, Wong TY. Metabolic syndrome components and age-related cataract: the Singapore Malay eye study. Invest Ophthalmol Vis Sci. 2011 Apr 14;52(5):2397–2404.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

April 14, 2011

Volume

52

Issue

5

Start / End Page

2397 / 2404

Location

United States

Related Subject Headings

  • Triglycerides
  • Singapore
  • Risk Factors
  • Prevalence
  • Ophthalmology & Optometry
  • Obesity
  • Middle Aged
  • Metabolic Syndrome
  • Male
  • Hypertension