Skip to main content
Journal cover image

Are myopic eyes less likely to have diabetic retinopathy?

Publication ,  Journal Article
Lim, LS; Lamoureux, E; Saw, SM; Tay, WT; Mitchell, P; Wong, TY
Published in: Ophthalmology
March 2010

PURPOSE: Eyes with myopia may be less likely to develop diabetic retinopathy (DR). The relationship between refractive error, ocular biometry, and DR therefore was investigated. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: Persons with diabetes from the Singapore Malay Eye Study (SiMES). METHODS: Diabetes mellitus was defined as random glucose of 11.1 mmol/l or more, use of diabetic medication, or a physician diagnosis of diabetes. Spherical equivalent refraction (SE) was assessed using an autokeratorefractometer and subjective refraction. Axial length (AL) and anterior chamber depth (ACD) were measured by IOLMaster (Carl Zeiss Meditec AG, Jena, Germany). Diabetic retinopathy was graded from retinal photographs. MAIN OUTCOME MEASURES: Any DR was defined by characteristic lesions defined by the Early Treatment Diabetic Retinopathy Study (ETDRS); moderate DR by ETDRS retinopathy severity scores of 43 or higher; and vision-threatening retinopathy by severe nonproliferative retinopathy, proliferative DR, or clinically significant macular edema. RESULTS: Of 3280 adult Malay participants (78.7% response), 629 persons with diabetes contributed to this analysis. In multivariate analyses adjusting for age, gender, education, height, cataract, hypertension, hemoglobin A1c, and other factors, eyes with myopic SE were less likely to have any DR (odds ratio [OR], 0.90; 95% confidence interval [CI], 0.84-0.96; P = 0.002, per 1-diopter [D] decrease), moderate DR (OR, 0.83; 95% CI, 0.73-0.93; P = 0.001, per 1-D decrease), and vision-threatening DR (OR, 0.77; 95% CI, 0.67-0.88; P<0.001, per 1-D decrease). Eyes with longer AL were less likely to have any DR (OR, 0.86; 95% CI, 0.75-0.99; P = 0.041, per 1-mm increase), moderate DR (OR, 0.80; 95% CI, 0.62-1.05; P = 0.11, per 1-mm increase), and vision-threatening DR (OR, 0.63; 95% CI, 0.40-0.99; P = 0.044, per mm increase). Eyes with deeper ACD were less likely to have moderate DR (OR, 0.32; 95% CI, 0.16-0.64; P = 0.001, per 1-mm increase) and vision-threatening DR (OR, 0.14; 95% CI, 0.06-0.36; P = 0.001, per 1-mm increase). CONCLUSIONS: Myopic refraction and longer AL are associated with a lower risk of DR, particularly vision-threatening retinopathy, without any evidence of a threshold.

Duke Scholars

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

March 2010

Volume

117

Issue

3

Start / End Page

524 / 530

Location

United States

Related Subject Headings

  • Singapore
  • Refraction, Ocular
  • Ophthalmology & Optometry
  • Myopia
  • Middle Aged
  • Male
  • Humans
  • Glycated Hemoglobin
  • Female
  • Eye
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lim, L. S., Lamoureux, E., Saw, S. M., Tay, W. T., Mitchell, P., & Wong, T. Y. (2010). Are myopic eyes less likely to have diabetic retinopathy? Ophthalmology, 117(3), 524–530. https://doi.org/10.1016/j.ophtha.2009.07.044
Lim, Laurence Shen, Ecosse Lamoureux, Seang Mei Saw, Wan Ting Tay, Paul Mitchell, and Tien Yin Wong. “Are myopic eyes less likely to have diabetic retinopathy?Ophthalmology 117, no. 3 (March 2010): 524–30. https://doi.org/10.1016/j.ophtha.2009.07.044.
Lim LS, Lamoureux E, Saw SM, Tay WT, Mitchell P, Wong TY. Are myopic eyes less likely to have diabetic retinopathy? Ophthalmology. 2010 Mar;117(3):524–30.
Lim, Laurence Shen, et al. “Are myopic eyes less likely to have diabetic retinopathy?Ophthalmology, vol. 117, no. 3, Mar. 2010, pp. 524–30. Pubmed, doi:10.1016/j.ophtha.2009.07.044.
Lim LS, Lamoureux E, Saw SM, Tay WT, Mitchell P, Wong TY. Are myopic eyes less likely to have diabetic retinopathy? Ophthalmology. 2010 Mar;117(3):524–530.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

March 2010

Volume

117

Issue

3

Start / End Page

524 / 530

Location

United States

Related Subject Headings

  • Singapore
  • Refraction, Ocular
  • Ophthalmology & Optometry
  • Myopia
  • Middle Aged
  • Male
  • Humans
  • Glycated Hemoglobin
  • Female
  • Eye