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Regular aspirin use and retinal microvascular signs: the Blue Mountains Eye Study.

Publication ,  Journal Article
Liew, G; Mitchell, P; Leeder, SR; Smith, W; Wong, TY; Wang, JJ
Published in: J Hypertens
July 2006

OBJECTIVE: Hypertension is closely related to microvascular abnormalities and there is increasing interest in agents that target the microvasculature. The effect of aspirin on the microvasculature has not been well studied. We examined the cross-sectional and longitudinal associations between regular aspirin use and retinal microvascular signs. DESIGN AND METHODS: We digitized retinal photographs from participants of the Blue Mountains Eye Study cohort (1992-1994, n = 3654, aged over 49 years, and 1997-1999, n = 2335) and used a computer-assisted method to measure average retinal arteriolar and venular diameters. Information on the frequency of aspirin use was collected, with regular aspirin use defined as weekly or daily. RESULTS: Regular aspirin users comprised 21.2% (n = 775) of the baseline population. At baseline and in individuals who were on one or more antihypertensive medication, regular aspirin use was found to be associated with retinal arterioles on average 3.6 mum (95% confidence interval 1.0, 6.2) wider than those of non-users or occasional aspirin users, after adjusting for age, blood pressure, smoking, diabetes, non-steroidal anti-inflammatory drug use and other variables. Increasing frequency of aspirin use was associated with increasing retinal arteriolar diameter (Ptrend < 0.01). At 5-year follow-up, regular users of aspirin and antihypertensive medication(s) had wider retinal arterioles than those who used aspirin less regularly. Neither antihypertensive medication use alone nor aspirin use alone was associated with wider retinal vessels. CONCLUSION: Our finding of a possible association between the combined use of aspirin and antihypertensive agent(s) and wider retinal arteriolar diameter warrants further investigation into the effects of aspirin on the microvasculature.

Duke Scholars

Published In

J Hypertens

DOI

ISSN

0263-6352

Publication Date

July 2006

Volume

24

Issue

7

Start / End Page

1329 / 1335

Location

Netherlands

Related Subject Headings

  • Retinal Vessels
  • Retinal Diseases
  • Photography
  • Middle Aged
  • Microcirculation
  • Male
  • Logistic Models
  • Linear Models
  • Image Processing, Computer-Assisted
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liew, G., Mitchell, P., Leeder, S. R., Smith, W., Wong, T. Y., & Wang, J. J. (2006). Regular aspirin use and retinal microvascular signs: the Blue Mountains Eye Study. J Hypertens, 24(7), 1329–1335. https://doi.org/10.1097/01.hjh.0000234113.33025.33
Liew, Gerald, Paul Mitchell, Stephen R. Leeder, Wayne Smith, Tien Yin Wong, and Jie Jin Wang. “Regular aspirin use and retinal microvascular signs: the Blue Mountains Eye Study.J Hypertens 24, no. 7 (July 2006): 1329–35. https://doi.org/10.1097/01.hjh.0000234113.33025.33.
Liew G, Mitchell P, Leeder SR, Smith W, Wong TY, Wang JJ. Regular aspirin use and retinal microvascular signs: the Blue Mountains Eye Study. J Hypertens. 2006 Jul;24(7):1329–35.
Liew, Gerald, et al. “Regular aspirin use and retinal microvascular signs: the Blue Mountains Eye Study.J Hypertens, vol. 24, no. 7, July 2006, pp. 1329–35. Pubmed, doi:10.1097/01.hjh.0000234113.33025.33.
Liew G, Mitchell P, Leeder SR, Smith W, Wong TY, Wang JJ. Regular aspirin use and retinal microvascular signs: the Blue Mountains Eye Study. J Hypertens. 2006 Jul;24(7):1329–1335.

Published In

J Hypertens

DOI

ISSN

0263-6352

Publication Date

July 2006

Volume

24

Issue

7

Start / End Page

1329 / 1335

Location

Netherlands

Related Subject Headings

  • Retinal Vessels
  • Retinal Diseases
  • Photography
  • Middle Aged
  • Microcirculation
  • Male
  • Logistic Models
  • Linear Models
  • Image Processing, Computer-Assisted
  • Humans