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Cardiovascular risk factors, inflammation, and corneal arcus: the singapore malay eye study.

Publication ,  Journal Article
Wu, R; Wang, JJ; Tai, ES; Wong, TY
Published in: Am J Ophthalmol
October 2010

PURPOSE: To examine the relationship of corneal arcus with cardiovascular risk factors and inflammation in Malay adults living in Singapore. DESIGN: Population-based cross-sectional study. METHODS: A total of 3280 Malays aged 40-80 years (out of 4168 eligible participants; 78.7% response rate) had a standardized interview, systemic and ocular examinations, and laboratory investigations, including measurement of C-reactive protein (CRP), chronic kidney disease, and peripheral artery disease. Corneal arcus was defined from anterior segment images taken with a slit-lamp camera. RESULTS: Corneal arcus was seen in 2345 out of 3260 participants who had anterior segment images (73.2%). After adjustment for age, gender, total cholesterol, serum glucose, and current smoking, many cardiovascular risk factors significantly associated with corneal arcus, including male gender (odds ratio [OR] 1.65, 95% confidence interval [CI] 1.27-2.03), older age (per 10 years, OR 4.49, 95% CI 3.91-5.15), higher body mass index (per kg/m(2), OR 1.02, 95% CI 1.00-1.04), higher levels of CRP (per 10 mg/L, OR 1.36, 95% CI 1.13-1.64), total cholesterol (per mmol/L, OR 1.21, 95% CI 1.11-1.32), low-density lipoprotein cholesterol (per mmol/L, OR 1.94, 95% CI 1.38-2.74), presence of peripheral artery disease (OR 3.85, 95% CI 1.29-11.5), chronic kidney disease (OR 1.14, 95% CI 1.03-1.38), and current smoking (OR 1.29, 95% CI 1.02-1.69). CONCLUSIONS: This study confirms known associations of traditional cardiovascular risk factors with corneal arcus in an Asian population. Additionally, corneal arcus may be associated with systemic inflammatory markers, peripheral artery disease, and chronic kidney disease.

Duke Scholars

Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

October 2010

Volume

150

Issue

4

Start / End Page

581 / 587.e1

Location

United States

Related Subject Headings

  • Singapore
  • Risk Factors
  • Prevalence
  • Peripheral Vascular Diseases
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Inflammation
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wu, R., Wang, J. J., Tai, E. S., & Wong, T. Y. (2010). Cardiovascular risk factors, inflammation, and corneal arcus: the singapore malay eye study. Am J Ophthalmol, 150(4), 581-587.e1. https://doi.org/10.1016/j.ajo.2010.04.028
Wu, Renyi, Jie Jin Wang, E Shyong Tai, and Tien Yin Wong. “Cardiovascular risk factors, inflammation, and corneal arcus: the singapore malay eye study.Am J Ophthalmol 150, no. 4 (October 2010): 581-587.e1. https://doi.org/10.1016/j.ajo.2010.04.028.
Wu R, Wang JJ, Tai ES, Wong TY. Cardiovascular risk factors, inflammation, and corneal arcus: the singapore malay eye study. Am J Ophthalmol. 2010 Oct;150(4):581-587.e1.
Wu, Renyi, et al. “Cardiovascular risk factors, inflammation, and corneal arcus: the singapore malay eye study.Am J Ophthalmol, vol. 150, no. 4, Oct. 2010, pp. 581-587.e1. Pubmed, doi:10.1016/j.ajo.2010.04.028.
Wu R, Wang JJ, Tai ES, Wong TY. Cardiovascular risk factors, inflammation, and corneal arcus: the singapore malay eye study. Am J Ophthalmol. 2010 Oct;150(4):581-587.e1.
Journal cover image

Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

October 2010

Volume

150

Issue

4

Start / End Page

581 / 587.e1

Location

United States

Related Subject Headings

  • Singapore
  • Risk Factors
  • Prevalence
  • Peripheral Vascular Diseases
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Inflammation
  • Humans
  • Female