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Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects.

Publication ,  Journal Article
Sng, CCA; Cackett, PD; Yeo, IY; Thalamuthu, A; Venkatraman, A; Venkataraman, D; Koh, AH; Tai, E-S; Wong, TY; Aung, T; Vithana, EN
Published in: Ophthalmic Res
2011

BACKGROUND/AIMS: Age-related macular degeneration (AMD) is a leading cause of visual impairment. A single-nucleotide polymorphism (SNP; rs3775291) in the Toll-like receptor 3 (TLR3) gene has recently been implicated in the pathogenesis of AMD in Caucasian populations. The aim of this study was to examine this association in Chinese persons with choroidal neovascularization (CNV) secondary to AMD and polypoidal choroidal vasculopathy (PCV). METHODS: This was an observational cross-sectional study in Singapore. Study subjects were of Chinese ethnicity and included patients with exudative maculopathy and normal control subjects. The diagnoses of CNV and PCV were made based on fundus examination, fluorescein angiography and indocyanine green angiography findings. Genomic DNA was extracted, and genotypes were determined by bidirectional DNA sequencing. We compared the allele and genotype frequencies between subjects with CNV and PCV with controls using the software PLINK. RESULTS: A total of 246 subjects with exudative maculopathy (consisting of 126 with CNV and 120 with PCV) and 274 normal control subjects were recruited. The distribution of rs3775291 SNP genotypes for CNV and PCV was not significantly different from that for normal controls. CONCLUSION: This study indicates that the TLR3 rs3775291 gene polymorphism is not associated with CNV and PCV in Singaporean Chinese patients.

Duke Scholars

Published In

Ophthalmic Res

DOI

EISSN

1423-0259

Publication Date

2011

Volume

45

Issue

4

Start / End Page

191 / 196

Location

Switzerland

Related Subject Headings

  • Toll-Like Receptor 3
  • Singapore
  • Polymorphism, Single Nucleotide
  • Polymerase Chain Reaction
  • Peripheral Vascular Diseases
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Humans
  • Genotype
 

Citation

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Sng, C. C. A., Cackett, P. D., Yeo, I. Y., Thalamuthu, A., Venkatraman, A., Venkataraman, D., … Vithana, E. N. (2011). Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects. Ophthalmic Res, 45(4), 191–196. https://doi.org/10.1159/000321387
Sng, Chelvin C. A., Peter D. Cackett, Ian Y. Yeo, Anbupalam Thalamuthu, Anandalakshmi Venkatraman, Divya Venkataraman, Adrian H. Koh, et al. “Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects.Ophthalmic Res 45, no. 4 (2011): 191–96. https://doi.org/10.1159/000321387.
Sng CCA, Cackett PD, Yeo IY, Thalamuthu A, Venkatraman A, Venkataraman D, et al. Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects. Ophthalmic Res. 2011;45(4):191–6.
Sng, Chelvin C. A., et al. “Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects.Ophthalmic Res, vol. 45, no. 4, 2011, pp. 191–96. Pubmed, doi:10.1159/000321387.
Sng CCA, Cackett PD, Yeo IY, Thalamuthu A, Venkatraman A, Venkataraman D, Koh AH, Tai E-S, Wong TY, Aung T, Vithana EN. Toll-like receptor 3 polymorphism rs3775291 is not associated with choroidal neovascularization or polypoidal choroidal vasculopathy in Chinese subjects. Ophthalmic Res. 2011;45(4):191–196.
Journal cover image

Published In

Ophthalmic Res

DOI

EISSN

1423-0259

Publication Date

2011

Volume

45

Issue

4

Start / End Page

191 / 196

Location

Switzerland

Related Subject Headings

  • Toll-Like Receptor 3
  • Singapore
  • Polymorphism, Single Nucleotide
  • Polymerase Chain Reaction
  • Peripheral Vascular Diseases
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Humans
  • Genotype