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Relationship of retinal vascular caliber with optic disc and macular structure.

Publication ,  Journal Article
Lim, LS; Saw, SM; Cheung, N; Mitchell, P; Wong, TY
Published in: Am J Ophthalmol
September 2009

PURPOSE: To examine the relationships of retinal vascular caliber with optic disc, macular, and retinal nerve fiber layer (RNFL) characteristics as measured with optical coherence tomography (OCT). DESIGN: Observational cross-sectional study. METHODS: This study included a subset of healthy children enrolled in the Singapore Cohort Study of the Risk Factors of Myopia (SCORM). Optic disc, macular, and RNFL morphology were measured with Stratus OCT 3. Digital retinal photography was performed and retinal arteriolar and venular caliber measured using validated imaging software. RESULTS: One hundred and four children (mean age 11.51 +/- 0.52 years; 50% male) were included. In multivariate analyses, smaller horizontal integrated rim width and rim area were associated with narrower retinal arterioles and venules (all P < .05), and shorter horizontal rim length was associated with narrower venules (P = .04). Optic disc diameter was not associated with arteriolar or venular caliber. Larger vertical cup-to-disc ratios and cup-to-disc-area ratios were associated with narrower venules but not arterioles (P = .01 and P = .003, respectively). A thinner average RNFL measurement was associated with narrower arterioles and venules, and smaller total macular volume was associated with narrower venules. CONCLUSIONS: Thinner optic disc rims and RNFL measurements were associated with narrower retinal arterioles and venules, and larger cup-to-disc ratios with narrower venules. These findings suggest that retinal vessel caliber varies systematically with morphologic differences in the optic nerve head, retina, and macula.

Duke Scholars

Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

September 2009

Volume

148

Issue

3

Start / End Page

368 / 375

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Singapore
  • Retinal Vessels
  • Retinal Ganglion Cells
  • Refraction, Ocular
  • Reference Values
  • Photography
  • Optic Disk
  • Ophthalmology & Optometry
  • Nerve Fibers
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lim, L. S., Saw, S. M., Cheung, N., Mitchell, P., & Wong, T. Y. (2009). Relationship of retinal vascular caliber with optic disc and macular structure. Am J Ophthalmol, 148(3), 368–375. https://doi.org/10.1016/j.ajo.2009.04.006
Lim, Laurence S., Seang Mei Saw, Ning Cheung, Paul Mitchell, and Tien Y. Wong. “Relationship of retinal vascular caliber with optic disc and macular structure.Am J Ophthalmol 148, no. 3 (September 2009): 368–75. https://doi.org/10.1016/j.ajo.2009.04.006.
Lim LS, Saw SM, Cheung N, Mitchell P, Wong TY. Relationship of retinal vascular caliber with optic disc and macular structure. Am J Ophthalmol. 2009 Sep;148(3):368–75.
Lim, Laurence S., et al. “Relationship of retinal vascular caliber with optic disc and macular structure.Am J Ophthalmol, vol. 148, no. 3, Sept. 2009, pp. 368–75. Pubmed, doi:10.1016/j.ajo.2009.04.006.
Lim LS, Saw SM, Cheung N, Mitchell P, Wong TY. Relationship of retinal vascular caliber with optic disc and macular structure. Am J Ophthalmol. 2009 Sep;148(3):368–375.
Journal cover image

Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

September 2009

Volume

148

Issue

3

Start / End Page

368 / 375

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Singapore
  • Retinal Vessels
  • Retinal Ganglion Cells
  • Refraction, Ocular
  • Reference Values
  • Photography
  • Optic Disk
  • Ophthalmology & Optometry
  • Nerve Fibers