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Influence of refractive error on optic disc topographic parameters: the singapore malay eye study.

Publication ,  Journal Article
Wu, R-Y; Wong, T-Y; Zheng, Y-F; Cheung, CY-L; Perera, SA; Saw, SM; Aung, T
Published in: Am J Ophthalmol
July 2011

PURPOSE: To examine the relationship between refractive error and optic disc topographic parameters and retinal nerve fiber layer (RNFL) thickness. DESIGN: Population-based cross-sectional study. METHODS: All 3,280 (78.7% response rate) persons of Asian Malay ethnicity 40 to 80 years of age underwent a standardized interview, ocular examinations, and optic disc imaging with the Heidelberg Retina Tomography II (HRT; Heidelberg Engineering). Associations between spherical equivalent (SE) and HRT parameters were evaluated by partial correlation analysis. RESULTS: There were 2,457 (74.9%) right eyes with good-quality HRT images for analyses. When compared with emmetropic eyes, highly myopic eyes (SE < -6.0 diopters) had greater disc area, rim area, rim volume, whereas hyperopic eyes (SE > 0.5 diopters) had significantly smaller disc area, rim area, and cross-sectional RNFL area (all P < .005). In partial correlation after adjustment for age, sex, body mass index, intraocular pressure, and optic disc area, increase of SE (toward hyperopia) was related significantly with greater cup area (partial correlation coefficient, r = 0.058; P = .004) and cup-to-disc area ratio (r = 0.058; P = .004) and with smaller optic disc area (r = -0.058; P = .004), rim area (r = 0.058; P = .004), and rim volume (r = -0.091; P < .001). CONCLUSIONS: This population-based study shows that refractive error is significantly (but weakly) associated with HRT parameters of disc area, cup area, rim area, cup-to-disc area ratio, and rim volume. The clinical significance of these associations need to be determined in further studies.

Duke Scholars

Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

July 2011

Volume

152

Issue

1

Start / End Page

81 / 86

Location

United States

Related Subject Headings

  • Singapore
  • Risk Factors
  • Retinal Ganglion Cells
  • Refractive Errors
  • Prevalence
  • Optic Nerve Diseases
  • Optic Disk
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wu, R.-Y., Wong, T.-Y., Zheng, Y.-F., Cheung, C.-L., Perera, S. A., Saw, S. M., & Aung, T. (2011). Influence of refractive error on optic disc topographic parameters: the singapore malay eye study. Am J Ophthalmol, 152(1), 81–86. https://doi.org/10.1016/j.ajo.2011.01.018
Wu, Ren-Yi, Tien-Yin Wong, Ying-Feng Zheng, Carol Yim-Lui Cheung, Shamira A. Perera, Seang Mei Saw, and Tin Aung. “Influence of refractive error on optic disc topographic parameters: the singapore malay eye study.Am J Ophthalmol 152, no. 1 (July 2011): 81–86. https://doi.org/10.1016/j.ajo.2011.01.018.
Wu R-Y, Wong T-Y, Zheng Y-F, Cheung CY-L, Perera SA, Saw SM, et al. Influence of refractive error on optic disc topographic parameters: the singapore malay eye study. Am J Ophthalmol. 2011 Jul;152(1):81–6.
Wu, Ren-Yi, et al. “Influence of refractive error on optic disc topographic parameters: the singapore malay eye study.Am J Ophthalmol, vol. 152, no. 1, July 2011, pp. 81–86. Pubmed, doi:10.1016/j.ajo.2011.01.018.
Wu R-Y, Wong T-Y, Zheng Y-F, Cheung CY-L, Perera SA, Saw SM, Aung T. Influence of refractive error on optic disc topographic parameters: the singapore malay eye study. Am J Ophthalmol. 2011 Jul;152(1):81–86.
Journal cover image

Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

July 2011

Volume

152

Issue

1

Start / End Page

81 / 86

Location

United States

Related Subject Headings

  • Singapore
  • Risk Factors
  • Retinal Ganglion Cells
  • Refractive Errors
  • Prevalence
  • Optic Nerve Diseases
  • Optic Disk
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Middle Aged