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Changes in abdominal obesity and age-related macular degeneration: the Atherosclerosis Risk in Communities Study.

Publication ,  Journal Article
Peeters, A; Magliano, DJ; Stevens, J; Duncan, BB; Klein, R; Wong, TY
Published in: Arch Ophthalmol
November 2008

OBJECTIVE: To examine the association between changes in waist-hip ratio (WHR), a measure of abdominal obesity, and age-related macular degeneration (AMD). METHODS: A total of 12 515 persons from a population-based cohort study, aged 45 to 64 years in 1987 to 1989, were followed up over 6 years. The percentage change in WHR during follow-up was ranked into sex-specific deciles; an increase in WHR was defined as the top 10% of change and a decrease in WHR as the bottom 10%. The association of increased or decreased WHR and presence of AMD at follow-up was determined using logistic regression adjusting for potential confounders. RESULTS: The average change in WHR was an increase of 2%, ranging from a decrease of 44% to an increase of 102%. A decrease in WHR of 3% or more was associated with 29% lower odds of any AMD (odds ratio = 0.71; 95% confidence interval, 0.52-0.97). This effect was most pronounced among obese participants at baseline, where a decrease in WHR was associated with 59% lower odds of AMD (odds ratio = 0.41; 95% confidence interval, 0.20-0.82). CONCLUSIONS: Middle-aged persons who had a 3% or greater reduction in WHR over time were less likely to have AMD, particularly among those who were initially obese.

Duke Scholars

Published In

Arch Ophthalmol

DOI

EISSN

1538-3601

Publication Date

November 2008

Volume

126

Issue

11

Start / End Page

1554 / 1560

Location

United States

Related Subject Headings

  • Waist-Hip Ratio
  • United States
  • Risk Factors
  • Ophthalmology & Optometry
  • Odds Ratio
  • Obesity
  • Middle Aged
  • Male
  • Macular Degeneration
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Peeters, A., Magliano, D. J., Stevens, J., Duncan, B. B., Klein, R., & Wong, T. Y. (2008). Changes in abdominal obesity and age-related macular degeneration: the Atherosclerosis Risk in Communities Study. Arch Ophthalmol, 126(11), 1554–1560. https://doi.org/10.1001/archopht.126.11.1554
Peeters, Anna, Dianna J. Magliano, June Stevens, Bruce B. Duncan, Ronald Klein, and Tien Y. Wong. “Changes in abdominal obesity and age-related macular degeneration: the Atherosclerosis Risk in Communities Study.Arch Ophthalmol 126, no. 11 (November 2008): 1554–60. https://doi.org/10.1001/archopht.126.11.1554.
Peeters A, Magliano DJ, Stevens J, Duncan BB, Klein R, Wong TY. Changes in abdominal obesity and age-related macular degeneration: the Atherosclerosis Risk in Communities Study. Arch Ophthalmol. 2008 Nov;126(11):1554–60.
Peeters, Anna, et al. “Changes in abdominal obesity and age-related macular degeneration: the Atherosclerosis Risk in Communities Study.Arch Ophthalmol, vol. 126, no. 11, Nov. 2008, pp. 1554–60. Pubmed, doi:10.1001/archopht.126.11.1554.
Peeters A, Magliano DJ, Stevens J, Duncan BB, Klein R, Wong TY. Changes in abdominal obesity and age-related macular degeneration: the Atherosclerosis Risk in Communities Study. Arch Ophthalmol. 2008 Nov;126(11):1554–1560.

Published In

Arch Ophthalmol

DOI

EISSN

1538-3601

Publication Date

November 2008

Volume

126

Issue

11

Start / End Page

1554 / 1560

Location

United States

Related Subject Headings

  • Waist-Hip Ratio
  • United States
  • Risk Factors
  • Ophthalmology & Optometry
  • Odds Ratio
  • Obesity
  • Middle Aged
  • Male
  • Macular Degeneration
  • Humans