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Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population.

Publication ,  Journal Article
Tai, ES; Sim, XL; Ong, TH; Wong, TY; Saw, SM; Aung, T; Kathiresan, S; Orho-Melander, M; Ordovas, JM; Tan, JT; Seielstad, M
Published in: J Lipid Res
March 2009

We conducted a cross-sectional study of Malay participants aged 40-80 years (n = 2,932) to examine the associations between polymorphisms at newly identified, lipid-associated loci with blood lipid levels and prevalent cardiovascular disease (CVD) in a Malay population in Asia. A polymorphism adjacent to the TRIB1 locus (rs17321515) was associated with elevated total cholesterol and LDL-cholesterol (LDL-C) after adjustment for age and sex (both P values <0.007) and with increased risk of coronary heart disease and CVD [odds ratio (OR) 1.23, 95% confidence interval (95% CI) 1.03-1.46; and OR 1.2, 95% CI 1.02-1.42, respectively] under an additive model of inheritance. In addition, using recessive models of inheritance, polymorphisms on chromosome 19 adjacent to the CILP2 and PBX4 loci (rs16996148) and on chromosome 1 at the GALNT2 locus (rs4846914) were associated with elevated HDL-C (P = 0.005) and lower LDL-C (P = 0.048), respectively. Although novel, the former is consistent with the association between this polymorphism and lower blood triglycerides observed in the initial studies conducted in populations of European ancestry. Neither showed statistically significant association with CVD. These observations should form the basis of further investigation to identify the causative polymorphisms at this locus, and also to understand the mechanistic roles that this protein may play in lipoprotein metabolism in Asians and other populations.

Duke Scholars

Published In

J Lipid Res

DOI

ISSN

0022-2275

Publication Date

March 2009

Volume

50

Issue

3

Start / End Page

514 / 520

Location

United States

Related Subject Headings

  • Singapore
  • Risk Factors
  • Protein Serine-Threonine Kinases
  • Polymorphism, Single Nucleotide
  • Molecular Epidemiology
  • Middle Aged
  • Male
  • Malaysia
  • Lipids
  • Intracellular Signaling Peptides and Proteins
 

Citation

APA
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ICMJE
MLA
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Tai, E. S., Sim, X. L., Ong, T. H., Wong, T. Y., Saw, S. M., Aung, T., … Seielstad, M. (2009). Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. J Lipid Res, 50(3), 514–520. https://doi.org/10.1194/jlr.M800456-JLR200
Tai, E Shyong, Xue Ling Sim, Twee Hee Ong, Tien Yin Wong, Seang Mei Saw, Tin Aung, Sekar Kathiresan, et al. “Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population.J Lipid Res 50, no. 3 (March 2009): 514–20. https://doi.org/10.1194/jlr.M800456-JLR200.
Tai, E. Shyong, et al. “Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population.J Lipid Res, vol. 50, no. 3, Mar. 2009, pp. 514–20. Pubmed, doi:10.1194/jlr.M800456-JLR200.
Tai ES, Sim XL, Ong TH, Wong TY, Saw SM, Aung T, Kathiresan S, Orho-Melander M, Ordovas JM, Tan JT, Seielstad M. Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. J Lipid Res. 2009 Mar;50(3):514–520.

Published In

J Lipid Res

DOI

ISSN

0022-2275

Publication Date

March 2009

Volume

50

Issue

3

Start / End Page

514 / 520

Location

United States

Related Subject Headings

  • Singapore
  • Risk Factors
  • Protein Serine-Threonine Kinases
  • Polymorphism, Single Nucleotide
  • Molecular Epidemiology
  • Middle Aged
  • Male
  • Malaysia
  • Lipids
  • Intracellular Signaling Peptides and Proteins