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Retinal microvascular signs and risk of stroke and stroke mortality.

Publication ,  Journal Article
Mitchell, P; Wang, JJ; Wong, TY; Smith, W; Klein, R; Leeder, SR
Published in: Neurology
October 11, 2005

OBJECTIVE: The purpose of this study was to assess the relation of retinal microvascular signs and incident stroke and stroke mortality in an older population. METHODS: The authors took retinal photographs on baseline participants (3,654 patients aged 49+ years) of the Blue Mountains Eye Study (1992 to 1994). They assessed the presence of retinopathy (microaneurysms, retinal hemorrhages) in participants without diabetes and retinal arteriolar signs in all participants using standardized grading protocols. Incident stroke/TIA/cerebrovascular death (combined stroke events) were identified at follow-up examinations during 1997 to 1999. RESULTS: During a 7-year period, 859 participants died, 97 (11.3%) of which died of cerebrovascular causes. Of survivors, 24 had confirmed incident stroke, and 11 had incident TIA. Combined stroke events were more frequent in participants with retinopathy (5.7%), with moderate/severe arteriovenous nicking (4.2%), or with focal arteriolar narrowing (7.2%) compared with those without (1.9%). After controlling for age, sex, systolic blood pressure, smoking, and self-rated health, retinopathy was significantly associated with combined stroke events (relative risk [RR] 1.7, 95% CI 1.0 to 2.8) in persons without diabetes. This association was stronger in those without severe hypertension (RR 2.7, CI 1.2 to 6.2) or in persons with two or more retinal microvascular signs (RR 2.7, CI 1.5 to 5.2). Generalized or focal arteriolar narrowing or arteriovenous nicking was not independently associated with combined stroke events after multivariate adjustment. CONCLUSIONS: In older Australians without diabetes, retinopathy signs predict stroke or stroke-related death independent of traditional stroke risk factors.

Duke Scholars

Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

October 11, 2005

Volume

65

Issue

7

Start / End Page

1005 / 1009

Location

United States

Related Subject Headings

  • Stroke
  • Risk Factors
  • Retinal Hemorrhage
  • Retinal Diseases
  • Retinal Artery
  • Predictive Value of Tests
  • Neurology & Neurosurgery
  • Mortality
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mitchell, P., Wang, J. J., Wong, T. Y., Smith, W., Klein, R., & Leeder, S. R. (2005). Retinal microvascular signs and risk of stroke and stroke mortality. Neurology, 65(7), 1005–1009. https://doi.org/10.1212/01.wnl.0000179177.15900.ca
Mitchell, P., J. J. Wang, T. Y. Wong, W. Smith, R. Klein, and S. R. Leeder. “Retinal microvascular signs and risk of stroke and stroke mortality.Neurology 65, no. 7 (October 11, 2005): 1005–9. https://doi.org/10.1212/01.wnl.0000179177.15900.ca.
Mitchell P, Wang JJ, Wong TY, Smith W, Klein R, Leeder SR. Retinal microvascular signs and risk of stroke and stroke mortality. Neurology. 2005 Oct 11;65(7):1005–9.
Mitchell, P., et al. “Retinal microvascular signs and risk of stroke and stroke mortality.Neurology, vol. 65, no. 7, Oct. 2005, pp. 1005–09. Pubmed, doi:10.1212/01.wnl.0000179177.15900.ca.
Mitchell P, Wang JJ, Wong TY, Smith W, Klein R, Leeder SR. Retinal microvascular signs and risk of stroke and stroke mortality. Neurology. 2005 Oct 11;65(7):1005–1009.

Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

October 11, 2005

Volume

65

Issue

7

Start / End Page

1005 / 1009

Location

United States

Related Subject Headings

  • Stroke
  • Risk Factors
  • Retinal Hemorrhage
  • Retinal Diseases
  • Retinal Artery
  • Predictive Value of Tests
  • Neurology & Neurosurgery
  • Mortality
  • Middle Aged
  • Male