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Donor risk index predicts graft failure reliably but not post-transplant infections.

Publication ,  Journal Article
Rosenberger, LH; Gillen, JR; Hranjec, T; Stokes, JB; Brayman, KL; Kumer, SC; Schmitt, TM; Sawyer, RG
Published in: Surg Infect (Larchmt)
April 2014

BACKGROUND: The Donor Risk Index (DRI) is used to predict graft survival following liver transplantation, but has not been used to predict post-operative infections in graft recipients. We hypothesized that lower-quality grafts would result in more frequent infectious complications. METHODS: Using a prospectively collected infection data set, we matched liver transplant recipients (and the respective allograft DRI scores) with their specific post-transplant infectious complications. All transplant recipients were organized by DRI score and divided into groups with low-DRI and high-DRI scores. RESULTS: We identified 378 liver transplants, with 189 recipients each in the low-DRI and high-DRI groups. The mean DRI scores for the low- and high-DRI-score groups were 1.14±0.01 and 1.74±0.02, respectively (p<0.0001 for the difference). The mean Model for End-Stage Liver Disease (MELD) scores were 26.25±0.53 and 24.76±0.55, respectively (p=0.052), and the mean number of infectious complications per patient were 1.60±0.19 and 1.94±0.24, respectively (p=0.26). Logistic regression showed only length of hospital stay and a history of vascular disease as being associated independently with infection, with a trend toward significance for MELD score (p=0.13). CONCLUSION: We conclude that although DRI score predicts graft-liver survival, infectious complications depend more heavily on recipient factors.

Duke Scholars

Published In

Surg Infect (Larchmt)

DOI

EISSN

1557-8674

Publication Date

April 2014

Volume

15

Issue

2

Start / End Page

94 / 98

Location

United States

Related Subject Headings

  • Young Adult
  • Tissue Donors
  • Surgery
  • Risk Factors
  • Prospective Studies
  • Postoperative Complications
  • Middle Aged
  • Liver Transplantation
  • Kidney Transplantation
  • Humans
 

Citation

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Rosenberger, L. H., Gillen, J. R., Hranjec, T., Stokes, J. B., Brayman, K. L., Kumer, S. C., … Sawyer, R. G. (2014). Donor risk index predicts graft failure reliably but not post-transplant infections. Surg Infect (Larchmt), 15(2), 94–98. https://doi.org/10.1089/sur.2013.035
Rosenberger, Laura H., Jacob R. Gillen, Tjasa Hranjec, Jayme B. Stokes, Kenneth L. Brayman, Sean C. Kumer, Timothy M. Schmitt, and Robert G. Sawyer. “Donor risk index predicts graft failure reliably but not post-transplant infections.Surg Infect (Larchmt) 15, no. 2 (April 2014): 94–98. https://doi.org/10.1089/sur.2013.035.
Rosenberger LH, Gillen JR, Hranjec T, Stokes JB, Brayman KL, Kumer SC, et al. Donor risk index predicts graft failure reliably but not post-transplant infections. Surg Infect (Larchmt). 2014 Apr;15(2):94–8.
Rosenberger, Laura H., et al. “Donor risk index predicts graft failure reliably but not post-transplant infections.Surg Infect (Larchmt), vol. 15, no. 2, Apr. 2014, pp. 94–98. Pubmed, doi:10.1089/sur.2013.035.
Rosenberger LH, Gillen JR, Hranjec T, Stokes JB, Brayman KL, Kumer SC, Schmitt TM, Sawyer RG. Donor risk index predicts graft failure reliably but not post-transplant infections. Surg Infect (Larchmt). 2014 Apr;15(2):94–98.
Journal cover image

Published In

Surg Infect (Larchmt)

DOI

EISSN

1557-8674

Publication Date

April 2014

Volume

15

Issue

2

Start / End Page

94 / 98

Location

United States

Related Subject Headings

  • Young Adult
  • Tissue Donors
  • Surgery
  • Risk Factors
  • Prospective Studies
  • Postoperative Complications
  • Middle Aged
  • Liver Transplantation
  • Kidney Transplantation
  • Humans