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Intraductal papillary mucinous neoplasm (IPMN) with extra-pancreatic mucin: a case series and review of the literature.

Publication ,  Journal Article
Rosenberger, LH; Stein, LH; Witkiewicz, AK; Kennedy, EP; Yeo, CJ
Published in: J Gastrointest Surg
April 2012

BACKGROUND: Intraductal papillary mucinous neoplasm (IPMN) is an increasingly recognized pancreatic neoplasm characterized by excessive mucin secretion by ductal epithelial cells resulting in a cystic dilation of the pancreatic duct. AIM: The objective of this study was to review Thomas Jefferson University's experience and the literature to determine the significance of extra-pancreatic mucin when associated with an IPMN. RESULTS: A retrospective analysis at our institution revealed only two cases of IPMN associated with extra-pancreatic mucin, which were classic IPMNs with rupture of the pancreatic duct and peritoneal mucin spillage. This specific finding is not previously described, although is assumed as five cases were reported in the literature with IPMN and mucin extension demonstrated by pseudomyxoma peritonei (PMP). We propose IPMN of the pancreas may be grossly compared to a mucocele of the appendix, as both are characterized by excessive secretion of mucin by ductal epithelial cells. A morbid complication of a mucocele is PMP. The presence of extra-pancreatic mucin with an IPMN could present a rare but important marker of the eventual seeding of tumor outside the primary IPMN. This has been documented with cases of iatrogenic spilling of pancreatic mucin, as well as multiple cases of IPMN associated with pseudomyxoma peritonei. CONCLUSIONS: At this time, there is scant reporting and consensus for the treatment of IPMN with extra-pancreatic mucin.

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Published In

J Gastrointest Surg

DOI

EISSN

1873-4626

Publication Date

April 2012

Volume

16

Issue

4

Start / End Page

762 / 770

Location

United States

Related Subject Headings

  • Surgery
  • Rupture, Spontaneous
  • Retrospective Studies
  • Pseudomyxoma Peritonei
  • Peritoneal Neoplasms
  • Pancreatic Neoplasms
  • Pancreatic Ducts
  • Neoplasms, Cystic, Mucinous, and Serous
  • Neoplasm Seeding
  • Mucins
 

Citation

APA
Chicago
ICMJE
MLA
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Rosenberger, L. H., Stein, L. H., Witkiewicz, A. K., Kennedy, E. P., & Yeo, C. J. (2012). Intraductal papillary mucinous neoplasm (IPMN) with extra-pancreatic mucin: a case series and review of the literature. J Gastrointest Surg, 16(4), 762–770. https://doi.org/10.1007/s11605-012-1823-8
Rosenberger, Laura H., Louis H. Stein, Agnieszka K. Witkiewicz, Eugene P. Kennedy, and Charles J. Yeo. “Intraductal papillary mucinous neoplasm (IPMN) with extra-pancreatic mucin: a case series and review of the literature.J Gastrointest Surg 16, no. 4 (April 2012): 762–70. https://doi.org/10.1007/s11605-012-1823-8.
Rosenberger LH, Stein LH, Witkiewicz AK, Kennedy EP, Yeo CJ. Intraductal papillary mucinous neoplasm (IPMN) with extra-pancreatic mucin: a case series and review of the literature. J Gastrointest Surg. 2012 Apr;16(4):762–70.
Rosenberger, Laura H., et al. “Intraductal papillary mucinous neoplasm (IPMN) with extra-pancreatic mucin: a case series and review of the literature.J Gastrointest Surg, vol. 16, no. 4, Apr. 2012, pp. 762–70. Pubmed, doi:10.1007/s11605-012-1823-8.
Rosenberger LH, Stein LH, Witkiewicz AK, Kennedy EP, Yeo CJ. Intraductal papillary mucinous neoplasm (IPMN) with extra-pancreatic mucin: a case series and review of the literature. J Gastrointest Surg. 2012 Apr;16(4):762–770.
Journal cover image

Published In

J Gastrointest Surg

DOI

EISSN

1873-4626

Publication Date

April 2012

Volume

16

Issue

4

Start / End Page

762 / 770

Location

United States

Related Subject Headings

  • Surgery
  • Rupture, Spontaneous
  • Retrospective Studies
  • Pseudomyxoma Peritonei
  • Peritoneal Neoplasms
  • Pancreatic Neoplasms
  • Pancreatic Ducts
  • Neoplasms, Cystic, Mucinous, and Serous
  • Neoplasm Seeding
  • Mucins