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The novel triad of dorsal agenesis of the pancreas with concurrent pancreatic ductal adenocarcinoma and nonalcoholic chronic calcific pancreatitis: a case series and review of the literature.

Publication ,  Journal Article
Rittenhouse, DW; Kennedy, EP; Mascaro, AA; Brumbaugh, JL; Stein, LH; Rosenberger, LH; Sauter, PK; Yeo, CJ; Lavu, H
Published in: J Gastrointest Surg
September 2011

INTRODUCTION: Dorsal agenesis of the pancreas (DAP) is a rare congenital anomaly, with only 44 cases having been reported in the English literature since 1966. MATERIALS AND METHODS: A retrospective review of our IRB-approved pancreatic surgery database was performed from November 2005 to November 2010 searching for cases of DAP. DISCUSSION: Disorders in the retinoic acid (Raldh) and hedgehog (Hh) signaling pathways, which appear to play a role in the development of DAP, have been implicated in other diseases of the pancreas such as pancreatic ductal adenocarcinoma (PDA) and nonalcoholic chronic calcific pancreatitis (NCCP). CONCLUSION: In this report, we describe three cases of DAP in the setting of PDA, two of which include the third component of NCCP. We provide a discussion of the clinical features of this novel triad and address the molecular pathways that relate to these respective diseases.

Duke Scholars

Published In

J Gastrointest Surg

DOI

EISSN

1873-4626

Publication Date

September 2011

Volume

15

Issue

9

Start / End Page

1643 / 1649

Location

United States

Related Subject Headings

  • Surgery
  • Signal Transduction
  • Retinal Dehydrogenase
  • Pancreatitis, Chronic
  • Pancreatic Neoplasms
  • Pancreas
  • Middle Aged
  • Male
  • Humans
  • Hedgehog Proteins
 

Citation

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Rittenhouse, D. W., Kennedy, E. P., Mascaro, A. A., Brumbaugh, J. L., Stein, L. H., Rosenberger, L. H., … Lavu, H. (2011). The novel triad of dorsal agenesis of the pancreas with concurrent pancreatic ductal adenocarcinoma and nonalcoholic chronic calcific pancreatitis: a case series and review of the literature. J Gastrointest Surg, 15(9), 1643–1649. https://doi.org/10.1007/s11605-011-1542-6
Rittenhouse, David W., Eugene P. Kennedy, Andres A. Mascaro, Jennifer L. Brumbaugh, Louis H. Stein, Laura H. Rosenberger, Patricia K. Sauter, Charles J. Yeo, and Harish Lavu. “The novel triad of dorsal agenesis of the pancreas with concurrent pancreatic ductal adenocarcinoma and nonalcoholic chronic calcific pancreatitis: a case series and review of the literature.J Gastrointest Surg 15, no. 9 (September 2011): 1643–49. https://doi.org/10.1007/s11605-011-1542-6.
Rittenhouse DW, Kennedy EP, Mascaro AA, Brumbaugh JL, Stein LH, Rosenberger LH, et al. The novel triad of dorsal agenesis of the pancreas with concurrent pancreatic ductal adenocarcinoma and nonalcoholic chronic calcific pancreatitis: a case series and review of the literature. J Gastrointest Surg. 2011 Sep;15(9):1643–9.
Rittenhouse, David W., et al. “The novel triad of dorsal agenesis of the pancreas with concurrent pancreatic ductal adenocarcinoma and nonalcoholic chronic calcific pancreatitis: a case series and review of the literature.J Gastrointest Surg, vol. 15, no. 9, Sept. 2011, pp. 1643–49. Pubmed, doi:10.1007/s11605-011-1542-6.
Rittenhouse DW, Kennedy EP, Mascaro AA, Brumbaugh JL, Stein LH, Rosenberger LH, Sauter PK, Yeo CJ, Lavu H. The novel triad of dorsal agenesis of the pancreas with concurrent pancreatic ductal adenocarcinoma and nonalcoholic chronic calcific pancreatitis: a case series and review of the literature. J Gastrointest Surg. 2011 Sep;15(9):1643–1649.
Journal cover image

Published In

J Gastrointest Surg

DOI

EISSN

1873-4626

Publication Date

September 2011

Volume

15

Issue

9

Start / End Page

1643 / 1649

Location

United States

Related Subject Headings

  • Surgery
  • Signal Transduction
  • Retinal Dehydrogenase
  • Pancreatitis, Chronic
  • Pancreatic Neoplasms
  • Pancreas
  • Middle Aged
  • Male
  • Humans
  • Hedgehog Proteins