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The significance of pre-operative coronary interventions on outcome after pancreas transplantation.

Publication ,  Journal Article
Laurence, JM; Barbas, AS; Sapisochin, G; Marquez, MA; Bazerbachi, F; Selzner, M; Norgate, A; McGilvray, ID; Schiff, J; Ross, H; Cattral, MS
Published in: Clin Transplant
March 2016

Pancreas transplant candidates are at very high risk of coronary vascular disease. We hypothesized that the requirement for pre-operative coronary intervention (PCI) may be associated with an adverse impact on short- and long-term outcomes. Retrospective analysis of 366 consecutive primary pancreas transplants was undertaken. Outcomes were compared between recipients who had undergone PCI (n = 48) and those who had not (n = 318). In 48% (23/48) of instances, the PCI was initiated by the transplant cardiology evaluation. The recipients undergoing PCI were older than those not undergoing PCI (47.6 yr vs. 41.9 yr, respectively, p < 0.0001). Although not statistically significant, there was a higher rate of post-operative major cardiovascular events (MCVE) in the PCI group (10.4%) compared with those not undergoing PCI (4.7%) (RR [95% CI]: 2.0 [0.90-4.5]; p = 0.17). In the long term, there were no differences in the rate of death with graft function (p = 0.77) or rejection (p = 0.17). There were no statistically significant differences between the groups with respect to patient (p = 0.54), kidney (p = 0.76), or pancreas (p = 0.63) graft survival. PCI is not a risk factor for short-term perioperative events, and long-term transplant outcomes are equivalent to patients not requiring PCI. PCI, by itself, should not be considered a contraindication for pancreas transplantation, but should raise awareness of perioperative risk.

Duke Scholars

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

March 2016

Volume

30

Issue

3

Start / End Page

233 / 240

Location

Denmark

Related Subject Headings

  • Survival Rate
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Prognosis
  • Preoperative Care
  • Postoperative Complications
  • Pancreatic Diseases
  • Pancreas Transplantation
  • Male
 

Citation

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MLA
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Laurence, J. M., Barbas, A. S., Sapisochin, G., Marquez, M. A., Bazerbachi, F., Selzner, M., … Cattral, M. S. (2016). The significance of pre-operative coronary interventions on outcome after pancreas transplantation. Clin Transplant, 30(3), 233–240. https://doi.org/10.1111/ctr.12681
Laurence, Jerome M., Andrew S. Barbas, Gonzalo Sapisochin, Max A. Marquez, Fateh Bazerbachi, Markus Selzner, Andrea Norgate, et al. “The significance of pre-operative coronary interventions on outcome after pancreas transplantation.Clin Transplant 30, no. 3 (March 2016): 233–40. https://doi.org/10.1111/ctr.12681.
Laurence JM, Barbas AS, Sapisochin G, Marquez MA, Bazerbachi F, Selzner M, et al. The significance of pre-operative coronary interventions on outcome after pancreas transplantation. Clin Transplant. 2016 Mar;30(3):233–40.
Laurence, Jerome M., et al. “The significance of pre-operative coronary interventions on outcome after pancreas transplantation.Clin Transplant, vol. 30, no. 3, Mar. 2016, pp. 233–40. Pubmed, doi:10.1111/ctr.12681.
Laurence JM, Barbas AS, Sapisochin G, Marquez MA, Bazerbachi F, Selzner M, Norgate A, McGilvray ID, Schiff J, Ross H, Cattral MS. The significance of pre-operative coronary interventions on outcome after pancreas transplantation. Clin Transplant. 2016 Mar;30(3):233–240.
Journal cover image

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

March 2016

Volume

30

Issue

3

Start / End Page

233 / 240

Location

Denmark

Related Subject Headings

  • Survival Rate
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Prognosis
  • Preoperative Care
  • Postoperative Complications
  • Pancreatic Diseases
  • Pancreas Transplantation
  • Male