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Inter-Relationships Between Retinal Vascular Caliber, Retinal Nerve Fiber Layer Thickness, and Glaucoma: A Mediation Analysis Approach.

Publication ,  Journal Article
Tham, Y-C; Siantar, RG; Cheung, CY-L; Tan, S-P; Koh, VT; Aung, T; Wong, TY; Cheng, C-Y
Published in: Invest Ophthalmol Vis Sci
July 1, 2016

PURPOSE: The purpose of this study was to explore the interrelationships among retinal vascular caliber, retinal nerve fiber layer (RNFL), and glaucoma; in particular, whether the relationship between narrower retinal vascular caliber and glaucoma is mediated by thinning of RNFL. METHODS: A total of 9407 participants, including 253 glaucoma and 195 primary open-angle glaucoma (POAG) cases from the Singapore Epidemiology of Eye Diseases Study were included in this study. All participants underwent standardized examinations. Glaucoma was defined according to International Society for Geographical and Epidemiologic Ophthalmology criteria. Logistic regression analyses were used to determine the total direct effects of retinal vascular calibers on glaucoma. Regression-based mediation analyses were used to evaluate the indirect effects of retinal vascular caliber on glaucoma through RNFL thinning. RESULTS: After we adjusted for relevant covariates, narrower retinal arteriolar caliber (per standard deviation [SD], 15.1-μm decrease) was associated with glaucoma (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.06-1.38) and POAG (OR, 1.23; 95% CI, 1.06-1.43). Similarly, narrower retinal venular caliber (per SD, 21.6μm decrease) was associated with glaucoma (OR, 1.51; 95% CI, 1.32-1.73) and POAG (OR, 1.64; 95% CI, 1.41-1.91). In addition, there were significant indirect effects of retinal vascular narrowing on glaucoma through thinning of RNFL (all P < 0.001), with mediated proportion of 36.9% and 12.9% in retinal arteriole- and venule-related analysis, respectively. CONCLUSIONS: Mediation analyses indicated that the effect of retinal vascular narrowing on glaucoma was partially the result of thinning of RNFL. These findings provide additional mechanistic insights linking retinal vascular narrowing and glaucoma.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

July 1, 2016

Volume

57

Issue

8

Start / End Page

3803 / 3809

Location

United States

Related Subject Headings

  • Singapore
  • Retinal Neurons
  • Retina
  • Prospective Studies
  • Optic Nerve
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tham, Y.-C., Siantar, R. G., Cheung, C.-L., Tan, S.-P., Koh, V. T., Aung, T., … Cheng, C.-Y. (2016). Inter-Relationships Between Retinal Vascular Caliber, Retinal Nerve Fiber Layer Thickness, and Glaucoma: A Mediation Analysis Approach. Invest Ophthalmol Vis Sci, 57(8), 3803–3809. https://doi.org/10.1167/iovs.15-18683
Tham, Yih-Chung, Rosalynn Grace Siantar, Carol Yim-Lui Cheung, Shu-Pei Tan, Victor T. Koh, Tin Aung, Tien Y. Wong, and Ching-Yu Cheng. “Inter-Relationships Between Retinal Vascular Caliber, Retinal Nerve Fiber Layer Thickness, and Glaucoma: A Mediation Analysis Approach.Invest Ophthalmol Vis Sci 57, no. 8 (July 1, 2016): 3803–9. https://doi.org/10.1167/iovs.15-18683.
Tham Y-C, Siantar RG, Cheung CY-L, Tan S-P, Koh VT, Aung T, et al. Inter-Relationships Between Retinal Vascular Caliber, Retinal Nerve Fiber Layer Thickness, and Glaucoma: A Mediation Analysis Approach. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3803–9.
Tham, Yih-Chung, et al. “Inter-Relationships Between Retinal Vascular Caliber, Retinal Nerve Fiber Layer Thickness, and Glaucoma: A Mediation Analysis Approach.Invest Ophthalmol Vis Sci, vol. 57, no. 8, July 2016, pp. 3803–09. Pubmed, doi:10.1167/iovs.15-18683.
Tham Y-C, Siantar RG, Cheung CY-L, Tan S-P, Koh VT, Aung T, Wong TY, Cheng C-Y. Inter-Relationships Between Retinal Vascular Caliber, Retinal Nerve Fiber Layer Thickness, and Glaucoma: A Mediation Analysis Approach. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3803–3809.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

July 1, 2016

Volume

57

Issue

8

Start / End Page

3803 / 3809

Location

United States

Related Subject Headings

  • Singapore
  • Retinal Neurons
  • Retina
  • Prospective Studies
  • Optic Nerve
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Middle Aged
  • Male
  • Humans