Skip to main content

Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations.

Publication ,  Journal Article
van Hecke, O; Kamerman, PR; Attal, N; Baron, R; Bjornsdottir, G; Bennett, DLH; Bennett, MI; Bouhassira, D; Diatchenko, L; Freeman, R; Raja, SN ...
Published in: Pain
November 2015

For genetic research to contribute more fully to furthering our knowledge of neuropathic pain, we require an agreed, valid, and feasible approach to phenotyping, to allow collaboration and replication in samples of sufficient size. Results from genetic studies on neuropathic pain have been inconsistent and have met with replication difficulties, in part because of differences in phenotypes used for case ascertainment. Because there is no consensus on the nature of these phenotypes, nor on the methods of collecting them, this study aimed to provide guidelines on collecting and reporting phenotypes in cases and controls for genetic studies. Consensus was achieved through a staged approach: (1) systematic literature review to identify all neuropathic pain phenotypes used in previous genetic studies; (2) Delphi survey to identify the most useful neuropathic pain phenotypes and their validity and feasibility; and (3) meeting of experts to reach consensus on the optimal phenotype(s) to be collected from patients with neuropathic pain for genetic studies. A basic "entry level" set of phenotypes was identified for any genetic study of neuropathic pain. This set identifies cases of "possible" neuropathic pain, and controls, and includes: (1) a validated symptom-based questionnaire to determine whether any pain is likely to be neuropathic; (2) body chart or checklist to identify whether the area of pain distribution is neuroanatomically logical; and (3) details of pain history (intensity, duration, any formal diagnosis). This NeuroPPIC "entry level" set of phenotypes can be expanded by more extensive and specific measures, as determined by scientific requirements and resource availability.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Pain

DOI

EISSN

1872-6623

Publication Date

November 2015

Volume

156

Issue

11

Start / End Page

2337 / 2353

Location

United States

Related Subject Headings

  • Phenotype
  • Pain Measurement
  • Neuralgia
  • International Cooperation
  • Humans
  • Expert Testimony
  • Delphi Technique
  • Databases, Bibliographic
  • Consensus
  • Anesthesiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
van Hecke, O., Kamerman, P. R., Attal, N., Baron, R., Bjornsdottir, G., Bennett, D. L. H., … Smith, B. H. (2015). Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations. Pain, 156(11), 2337–2353. https://doi.org/10.1097/j.pain.0000000000000335
Hecke, Oliver van, Peter R. Kamerman, Nadine Attal, Ralf Baron, Gyda Bjornsdottir, David L. H. Bennett, Michael I. Bennett, et al. “Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations.Pain 156, no. 11 (November 2015): 2337–53. https://doi.org/10.1097/j.pain.0000000000000335.
van Hecke O, Kamerman PR, Attal N, Baron R, Bjornsdottir G, Bennett DLH, et al. Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations. Pain. 2015 Nov;156(11):2337–53.
van Hecke, Oliver, et al. “Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations.Pain, vol. 156, no. 11, Nov. 2015, pp. 2337–53. Pubmed, doi:10.1097/j.pain.0000000000000335.
van Hecke O, Kamerman PR, Attal N, Baron R, Bjornsdottir G, Bennett DLH, Bennett MI, Bouhassira D, Diatchenko L, Freeman R, Freynhagen R, Haanpää M, Jensen TS, Raja SN, Rice ASC, Seltzer Z, Thorgeirsson TE, Yarnitsky D, Smith BH. Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations. Pain. 2015 Nov;156(11):2337–2353.

Published In

Pain

DOI

EISSN

1872-6623

Publication Date

November 2015

Volume

156

Issue

11

Start / End Page

2337 / 2353

Location

United States

Related Subject Headings

  • Phenotype
  • Pain Measurement
  • Neuralgia
  • International Cooperation
  • Humans
  • Expert Testimony
  • Delphi Technique
  • Databases, Bibliographic
  • Consensus
  • Anesthesiology