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Single Nucleotide Polymorphism Heritability of a General Psychopathology Factor in Children.

Publication ,  Journal Article
Neumann, A; Pappa, I; Lahey, BB; Verhulst, FC; Medina-Gomez, C; Jaddoe, VW; Bakermans-Kranenburg, MJ; Moffitt, TE; van IJzendoorn, MH; Tiemeier, H
Published in: Journal of the American Academy of Child and Adolescent Psychiatry
December 2016

Co-occurrence of mental disorders is commonly observed, but the etiology underlying this observation is poorly understood. Studies in adolescents and adults have identified a general psychopathology factor associated with a high risk for different psychiatric disorders. We defined a multi-informant general psychopathology factor in school-aged children and estimated its single nucleotide polymorphism (SNP) heritability. The goal was to test the hypothesis that child behavioral and emotional problems are under the influence of highly pleiotropic common autosomal genetic variants that nonspecifically increase the risk for different dimensions of psychopathology.Children from the Generation R cohort were repeatedly assessed between ages 6 to 8 years. Child behavior problems were reported by parents, teachers, and children. Confirmatory factor analysis estimated a general psychopathology factor across informants using various psychiatric problem scales. Validation of the general psychopathology factor was based on IQ and temperamental measures. Genome-wide complex trait analysis (GCTA) was used to estimate the SNP heritability (N = 2,115).The general psychopathology factor was associated with lower IQ, higher negative affectivity, and lower effortful control, but not with surgency. Importantly, the general psychopathology factor showed a significant SNP heritability of 38% (SE = 0.16, p = .008).Common autosomal SNPs are pleiotropically associated with internalizing, externalizing, and other child behavior problems, and underlie a general psychopathology factor in childhood.

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Published In

Journal of the American Academy of Child and Adolescent Psychiatry

DOI

EISSN

1527-5418

ISSN

0890-8567

Publication Date

December 2016

Volume

55

Issue

12

Start / End Page

1038 / 1045.e4

Related Subject Headings

  • Quantitative Trait, Heritable
  • Problem Behavior
  • Polymorphism, Single Nucleotide
  • Mental Disorders
  • Male
  • Humans
  • Genome-Wide Association Study
  • Genetic Pleiotropy
  • Female
  • Developmental & Child Psychology
 

Citation

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Neumann, A., Pappa, I., Lahey, B. B., Verhulst, F. C., Medina-Gomez, C., Jaddoe, V. W., … Tiemeier, H. (2016). Single Nucleotide Polymorphism Heritability of a General Psychopathology Factor in Children. Journal of the American Academy of Child and Adolescent Psychiatry, 55(12), 1038-1045.e4. https://doi.org/10.1016/j.jaac.2016.09.498
Neumann, Alexander, Irene Pappa, Benjamin B. Lahey, Frank C. Verhulst, Carolina Medina-Gomez, Vincent W. Jaddoe, Marian J. Bakermans-Kranenburg, Terrie E. Moffitt, Marinus H. van IJzendoorn, and Henning Tiemeier. “Single Nucleotide Polymorphism Heritability of a General Psychopathology Factor in Children.Journal of the American Academy of Child and Adolescent Psychiatry 55, no. 12 (December 2016): 1038-1045.e4. https://doi.org/10.1016/j.jaac.2016.09.498.
Neumann A, Pappa I, Lahey BB, Verhulst FC, Medina-Gomez C, Jaddoe VW, et al. Single Nucleotide Polymorphism Heritability of a General Psychopathology Factor in Children. Journal of the American Academy of Child and Adolescent Psychiatry. 2016 Dec;55(12):1038-1045.e4.
Neumann, Alexander, et al. “Single Nucleotide Polymorphism Heritability of a General Psychopathology Factor in Children.Journal of the American Academy of Child and Adolescent Psychiatry, vol. 55, no. 12, Dec. 2016, pp. 1038-1045.e4. Epmc, doi:10.1016/j.jaac.2016.09.498.
Neumann A, Pappa I, Lahey BB, Verhulst FC, Medina-Gomez C, Jaddoe VW, Bakermans-Kranenburg MJ, Moffitt TE, van IJzendoorn MH, Tiemeier H. Single Nucleotide Polymorphism Heritability of a General Psychopathology Factor in Children. Journal of the American Academy of Child and Adolescent Psychiatry. 2016 Dec;55(12):1038-1045.e4.
Journal cover image

Published In

Journal of the American Academy of Child and Adolescent Psychiatry

DOI

EISSN

1527-5418

ISSN

0890-8567

Publication Date

December 2016

Volume

55

Issue

12

Start / End Page

1038 / 1045.e4

Related Subject Headings

  • Quantitative Trait, Heritable
  • Problem Behavior
  • Polymorphism, Single Nucleotide
  • Mental Disorders
  • Male
  • Humans
  • Genome-Wide Association Study
  • Genetic Pleiotropy
  • Female
  • Developmental & Child Psychology