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Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population.

Publication ,  Journal Article
Jia, M; Zhu, M; Zhou, F; Wang, M; Sun, M; Yang, Y; Wang, X; Wang, J; Jin, L; Xiang, J; Zhang, Y; Chang, J; Wei, Q
Published in: Int J Cancer
February 15, 2017

The JNK and p38α pathways play an important role in carcinogenesis. Therefore, we hypothesize that single nucleotide polymorphisms (SNPs) of genes involved in these pathways are associated with risk of lung cancer. We first selected and genotyped 11 independent SNPs of the JNK and p38α pathway-related genes in a discovery set of 1,002 non-small cell lung cancer (NSCLC) cases and 1,025 cancer-free controls of Eastern Chinese. Then, we validated those significant SNPs in a replication set of 1,333 NSCLC cases and 1,339 cancer-free controls of Eastern Chinese. Multifactor dimensionality reduction (MDR) and classification and regression tree (CART) analyses were used to identify interactions between significant SNPs and other covariates. In both discovery and replication as well as their pooled analysis, carriers of GADD45G rs8252T variant genotypes had a significantly lower risk of NSCLC (adjusted OR = 0.81 and 0.79, 95% CI = 0.72-0.92 and 0.64-0.99 and p = 0.001 and 0.040 for dominant and recessive genetic models, respectively) and carriers of MAP2K7 rs3679T variant genotypes had an increased risk of NSCLC (adjusted OR = 1.19 and 1.29, 95% CI = 1.05-1.34 and 1.09-1.54 and p = 0.005 and 0.004 for dominant and recessive genetic models, respectively). Furthermore, rs8252 variant CT/TT carriers showed significantly higher levels of GADD45G mRNA expression than CC carriers in the target tissues. We observed some evidence of interactions between rs8252 genotypes and sex in NSCLC risk. These results indicate that GADD45G rs8252 and MAP2K7 rs3679 SNPs may be susceptibility biomarkers for NSCLC in Eastern Chinese populations.

Duke Scholars

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Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

February 15, 2017

Volume

140

Issue

4

Start / End Page

807 / 817

Location

United States

Related Subject Headings

  • Sex Factors
  • Risk Factors
  • Risk
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Mitogen-Activated Protein Kinase 14
  • Middle Aged
  • Male
  • MAP Kinase Signaling System
  • MAP Kinase Kinase 7
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jia, M., Zhu, M., Zhou, F., Wang, M., Sun, M., Yang, Y., … Wei, Q. (2017). Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population. Int J Cancer, 140(4), 807–817. https://doi.org/10.1002/ijc.30508
Jia, Ming, Meiling Zhu, Fei Zhou, Mengyun Wang, Menghong Sun, Yajun Yang, Xiaofeng Wang, et al. “Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population.Int J Cancer 140, no. 4 (February 15, 2017): 807–17. https://doi.org/10.1002/ijc.30508.
Jia M, Zhu M, Zhou F, Wang M, Sun M, Yang Y, et al. Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population. Int J Cancer. 2017 Feb 15;140(4):807–17.
Jia, Ming, et al. “Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population.Int J Cancer, vol. 140, no. 4, Feb. 2017, pp. 807–17. Pubmed, doi:10.1002/ijc.30508.
Jia M, Zhu M, Zhou F, Wang M, Sun M, Yang Y, Wang X, Wang J, Jin L, Xiang J, Zhang Y, Chang J, Wei Q. Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population. Int J Cancer. 2017 Feb 15;140(4):807–817.

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

February 15, 2017

Volume

140

Issue

4

Start / End Page

807 / 817

Location

United States

Related Subject Headings

  • Sex Factors
  • Risk Factors
  • Risk
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Mitogen-Activated Protein Kinase 14
  • Middle Aged
  • Male
  • MAP Kinase Signaling System
  • MAP Kinase Kinase 7