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Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products.

Publication ,  Journal Article
England, LJ; Aagaard, K; Bloch, M; Conway, K; Cosgrove, K; Grana, R; Gould, TJ; Hatsukami, D; Jensen, F; Kandel, D; Lanphear, B; Leslie, F ...
Published in: Neurosci Biobehav Rev
January 2017

While the health risks associated with adult cigarette smoking have been well described, effects of nicotine exposure during periods of developmental vulnerability are often overlooked. Using MEDLINE and PubMed literature searches, books, reports and expert opinion, a transdisciplinary group of scientists reviewed human and animal research on the health effects of exposure to nicotine during pregnancy and adolescence. A synthesis of this research supports that nicotine contributes critically to adverse effects of gestational tobacco exposure, including reduced pulmonary function, auditory processing defects, impaired infant cardiorespiratory function, and may contribute to cognitive and behavioral deficits in later life. Nicotine exposure during adolescence is associated with deficits in working memory, attention, and auditory processing, as well as increased impulsivity and anxiety. Finally, recent animal studies suggest that nicotine has a priming effect that increases addiction liability for other drugs. The evidence that nicotine adversely affects fetal and adolescent development is sufficient to warrant public health measures to protect pregnant women, children, and adolescents from nicotine exposure.

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Published In

Neurosci Biobehav Rev

DOI

EISSN

1873-7528

Publication Date

January 2017

Volume

72

Start / End Page

176 / 189

Location

United States

Related Subject Headings

  • Smoking
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Nicotine
  • Nicotiana
  • Humans
  • Fetus
  • Female
  • Behavioral Science & Comparative Psychology
  • Animals
 

Citation

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England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., … Wakschlag, L. (2017). Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products. Neurosci Biobehav Rev, 72, 176–189. https://doi.org/10.1016/j.neubiorev.2016.11.013
England, Lucinda J., Kjersti Aagaard, Michele Bloch, Kevin Conway, Kelly Cosgrove, Rachel Grana, Thomas J. Gould, et al. “Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products.Neurosci Biobehav Rev 72 (January 2017): 176–89. https://doi.org/10.1016/j.neubiorev.2016.11.013.
England LJ, Aagaard K, Bloch M, Conway K, Cosgrove K, Grana R, et al. Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products. Neurosci Biobehav Rev. 2017 Jan;72:176–89.
England, Lucinda J., et al. “Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products.Neurosci Biobehav Rev, vol. 72, Jan. 2017, pp. 176–89. Pubmed, doi:10.1016/j.neubiorev.2016.11.013.
England LJ, Aagaard K, Bloch M, Conway K, Cosgrove K, Grana R, Gould TJ, Hatsukami D, Jensen F, Kandel D, Lanphear B, Leslie F, Pauly JR, Neiderhiser J, Rubinstein M, Slotkin TA, Spindel E, Stroud L, Wakschlag L. Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products. Neurosci Biobehav Rev. 2017 Jan;72:176–189.
Journal cover image

Published In

Neurosci Biobehav Rev

DOI

EISSN

1873-7528

Publication Date

January 2017

Volume

72

Start / End Page

176 / 189

Location

United States

Related Subject Headings

  • Smoking
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Nicotine
  • Nicotiana
  • Humans
  • Fetus
  • Female
  • Behavioral Science & Comparative Psychology
  • Animals