Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials.

Publication ,  Journal Article
Orbai, A-M; de Wit, M; Mease, P; Shea, JA; Gossec, L; Leung, YY; Tillett, W; Elmamoun, M; Callis Duffin, K; Campbell, W; Christensen, R ...
Published in: Ann Rheum Dis
April 2017

OBJECTIVE: To identify a core set of domains (outcomes) to be measured in psoriatic arthritis (PsA) clinical trials that represent both patients' and physicians' priorities. METHODS: We conducted (1) a systematic literature review (SLR) of domains assessed in PsA; (2) international focus groups to identify domains important to people with PsA; (3) two international surveys with patients and physicians to prioritise domains; (4) an international face-to-face meeting with patients and physicians using the nominal group technique method to agree on the most important domains; and (5) presentation and votes at the Outcome Measures in Rheumatology (OMERACT) conference in May 2016. All phases were performed in collaboration with patient research partners. RESULTS: We identified 39 unique domains through the SLR (24 domains) and international focus groups (34 domains). 50 patients and 75 physicians rated domain importance. During the March 2016 consensus meeting, 12 patients and 12 physicians agreed on 10 candidate domains. Then, 49 patients and 71 physicians rated these domains' importance. Five were important to >70% of both groups: musculoskeletal disease activity, skin disease activity, structural damage, pain and physical function. Fatigue and participation were important to >70% of patients. Patient global and systemic inflammation were important to >70% of physicians. The updated PsA core domain set endorsed by 90% of OMERACT 2016 participants includes musculoskeletal disease activity, skin disease activity, pain, patient global, physical function, health-related quality of life, fatigue and systemic inflammation. CONCLUSIONS: The updated PsA core domain set incorporates patients' and physicians' priorities and evolving PsA research. Next steps include identifying outcome measures that adequately assess these domains.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Ann Rheum Dis

DOI

EISSN

1468-2060

Publication Date

April 2017

Volume

76

Issue

4

Start / End Page

673 / 680

Location

England

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Review Literature as Topic
  • Quality of Life
  • Physicians
  • Patient Reported Outcome Measures
  • Pain
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Orbai, A.-M., de Wit, M., Mease, P., Shea, J. A., Gossec, L., Leung, Y. Y., … Ogdie, A. (2017). International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials. Ann Rheum Dis, 76(4), 673–680. https://doi.org/10.1136/annrheumdis-2016-210242
Orbai, Ana-Maria, Maarten de Wit, Philip Mease, Judy A. Shea, Laure Gossec, Ying Ying Leung, William Tillett, et al. “International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials.Ann Rheum Dis 76, no. 4 (April 2017): 673–80. https://doi.org/10.1136/annrheumdis-2016-210242.
Orbai A-M, de Wit M, Mease P, Shea JA, Gossec L, Leung YY, et al. International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials. Ann Rheum Dis. 2017 Apr;76(4):673–80.
Orbai, Ana-Maria, et al. “International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials.Ann Rheum Dis, vol. 76, no. 4, Apr. 2017, pp. 673–80. Pubmed, doi:10.1136/annrheumdis-2016-210242.
Orbai A-M, de Wit M, Mease P, Shea JA, Gossec L, Leung YY, Tillett W, Elmamoun M, Callis Duffin K, Campbell W, Christensen R, Coates L, Dures E, Eder L, FitzGerald O, Gladman D, Goel N, Grieb SD, Hewlett S, Hoejgaard P, Kalyoncu U, Lindsay C, McHugh N, Shea B, Steinkoenig I, Strand V, Ogdie A. International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials. Ann Rheum Dis. 2017 Apr;76(4):673–680.

Published In

Ann Rheum Dis

DOI

EISSN

1468-2060

Publication Date

April 2017

Volume

76

Issue

4

Start / End Page

673 / 680

Location

England

Related Subject Headings

  • Young Adult
  • Treatment Outcome
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Review Literature as Topic
  • Quality of Life
  • Physicians
  • Patient Reported Outcome Measures
  • Pain
  • Middle Aged