Skip to main content
Journal cover image

Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat-water phantom.

Publication ,  Journal Article
Hernando, D; Sharma, SD; Aliyari Ghasabeh, M; Alvis, BD; Arora, SS; Hamilton, G; Pan, L; Shaffer, JM; Sofue, K; Szeverenyi, NM; Welch, EB ...
Published in: Magn Reson Med
April 2017

PURPOSE: To evaluate the accuracy and reproducibility of quantitative chemical shift-encoded (CSE) MRI to quantify proton-density fat-fraction (PDFF) in a fat-water phantom across sites, vendors, field strengths, and protocols. METHODS: Six sites (Philips, Siemens, and GE Healthcare) participated in this study. A phantom containing multiple vials with various oil/water suspensions (PDFF:0%-100%) was built, shipped to each site, and scanned at 1.5T and 3T using two CSE protocols per field strength. Confounder-corrected PDFF maps were reconstructed using a common algorithm. To assess accuracy, PDFF bias and linear regression with the known PDFF were calculated. To assess reproducibility, measurements were compared across sites, vendors, field strengths, and protocols using analysis of covariance (ANCOVA), Bland-Altman analysis, and the intraclass correlation coefficient (ICC). RESULTS: PDFF measurements revealed an overall absolute bias (across sites, field strengths, and protocols) of 0.22% (95% confidence interval, 0.07%-0.38%) and R2  > 0.995 relative to the known PDFF at each site, field strength, and protocol, with a slope between 0.96 and 1.02 and an intercept between -0.56% and 1.13%. ANCOVA did not reveal effects of field strength (P = 0.36) or protocol (P = 0.19). There was a significant effect of vendor (F = 25.13, P = 1.07 × 10-10 ) with a bias of -0.37% (Philips) and -1.22% (Siemens) relative to GE Healthcare. The overall ICC was 0.999. CONCLUSION: CSE-based fat quantification is accurate and reproducible across sites, vendors, field strengths, and protocols. Magn Reson Med 77:1516-1524, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

April 2017

Volume

77

Issue

4

Start / End Page

1516 / 1524

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Protons
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Equipment Failure Analysis
  • Equipment Design
  • Body Water
  • Adipose Tissue
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hernando, D., Sharma, S. D., Aliyari Ghasabeh, M., Alvis, B. D., Arora, S. S., Hamilton, G., … Reeder, S. B. (2017). Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat-water phantom. Magn Reson Med, 77(4), 1516–1524. https://doi.org/10.1002/mrm.26228
Hernando, Diego, Samir D. Sharma, Mounes Aliyari Ghasabeh, Bret D. Alvis, Sandeep S. Arora, Gavin Hamilton, Li Pan, et al. “Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat-water phantom.Magn Reson Med 77, no. 4 (April 2017): 1516–24. https://doi.org/10.1002/mrm.26228.
Hernando D, Sharma SD, Aliyari Ghasabeh M, Alvis BD, Arora SS, Hamilton G, et al. Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat-water phantom. Magn Reson Med. 2017 Apr;77(4):1516–24.
Hernando, Diego, et al. “Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat-water phantom.Magn Reson Med, vol. 77, no. 4, Apr. 2017, pp. 1516–24. Pubmed, doi:10.1002/mrm.26228.
Hernando D, Sharma SD, Aliyari Ghasabeh M, Alvis BD, Arora SS, Hamilton G, Pan L, Shaffer JM, Sofue K, Szeverenyi NM, Welch EB, Yuan Q, Bashir MR, Kamel IR, Rice MJ, Sirlin CB, Yokoo T, Reeder SB. Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat-water phantom. Magn Reson Med. 2017 Apr;77(4):1516–1524.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

April 2017

Volume

77

Issue

4

Start / End Page

1516 / 1524

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Protons
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Equipment Failure Analysis
  • Equipment Design
  • Body Water
  • Adipose Tissue