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Treatment of non-Hodgkin's lymphoma with chemoradiotherapy and allogenic marrow transplantation.

Publication ,  Journal Article
Appelbaum, FR; Thomas, ED; Buckner, CD; Clift, RA; Deeg, HJ; Fefer, A; Neiman, PE; Sanders, J; Stewart, P; Storb, R
Published in: Hematol Oncol
1983

Twenty patients with disseminated non-Hodgkin's lymphoma who failed conventional combination chemotherapy were treated with high-dose chemoradiotherapy and marrow transplantation from an HLA-identical sibling. Four patients remain alive in complete remission from 153 to 784 days after transplant. The reason for failure in eight cases was persistence or relapse of lymphoma. In the other eight cases, death was due to a complication of the transplant procedure including interstitial pneumonia, veno-occlusive disease of the liver, graft-versus-host disease, or infection. These results appear similar to those previously observed in patients with acute leukemia in relapse in that a small but significant proportion of patients with otherwise end-stage disease may achieve prolonged complete remission after intensive chemoradiotherapy and allogeneic marrow transplantation.

Duke Scholars

Published In

Hematol Oncol

DOI

ISSN

0278-0232

Publication Date

1983

Volume

1

Issue

2

Start / End Page

149 / 157

Location

England

Related Subject Headings

  • Transplantation, Homologous
  • Pulmonary Fibrosis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Lymphoma
  • Immunology
  • Humans
  • Graft vs Host Disease
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Appelbaum, F. R., Thomas, E. D., Buckner, C. D., Clift, R. A., Deeg, H. J., Fefer, A., … Storb, R. (1983). Treatment of non-Hodgkin's lymphoma with chemoradiotherapy and allogenic marrow transplantation. Hematol Oncol, 1(2), 149–157. https://doi.org/10.1002/hon.2900010205
Appelbaum, F. R., E. D. Thomas, C. D. Buckner, R. A. Clift, H. J. Deeg, A. Fefer, P. E. Neiman, J. Sanders, P. Stewart, and R. Storb. “Treatment of non-Hodgkin's lymphoma with chemoradiotherapy and allogenic marrow transplantation.Hematol Oncol 1, no. 2 (1983): 149–57. https://doi.org/10.1002/hon.2900010205.
Appelbaum FR, Thomas ED, Buckner CD, Clift RA, Deeg HJ, Fefer A, et al. Treatment of non-Hodgkin's lymphoma with chemoradiotherapy and allogenic marrow transplantation. Hematol Oncol. 1983;1(2):149–57.
Appelbaum, F. R., et al. “Treatment of non-Hodgkin's lymphoma with chemoradiotherapy and allogenic marrow transplantation.Hematol Oncol, vol. 1, no. 2, 1983, pp. 149–57. Pubmed, doi:10.1002/hon.2900010205.
Appelbaum FR, Thomas ED, Buckner CD, Clift RA, Deeg HJ, Fefer A, Neiman PE, Sanders J, Stewart P, Storb R. Treatment of non-Hodgkin's lymphoma with chemoradiotherapy and allogenic marrow transplantation. Hematol Oncol. 1983;1(2):149–157.
Journal cover image

Published In

Hematol Oncol

DOI

ISSN

0278-0232

Publication Date

1983

Volume

1

Issue

2

Start / End Page

149 / 157

Location

England

Related Subject Headings

  • Transplantation, Homologous
  • Pulmonary Fibrosis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Lymphoma
  • Immunology
  • Humans
  • Graft vs Host Disease
  • Female