Aptamers as Therapeutics.
Publication
, Journal Article
Nimjee, SM; White, RR; Becker, RC; Sullenger, BA
Published in: Annu Rev Pharmacol Toxicol
January 6, 2017
Aptamers are single-stranded nucleic acid molecules that bind to and inhibit proteins and are commonly produced by systematic evolution of ligands by exponential enrichment (SELEX). Aptamers undergo extensive pharmacological revision, which alters affinity, specificity, and therapeutic half-life, tailoring each drug for a specific clinical need. The first therapeutic aptamer was described 25 years ago. Thus far, one aptamer has been approved for clinical use, and numerous others are in preclinical or clinical development. This review presents a short history of aptamers and SELEX, describes their pharmacological development and optimization, and reviews potential treatment of diseases including visual disorders, thrombosis, and cancer.
Duke Scholars
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Published In
Annu Rev Pharmacol Toxicol
DOI
EISSN
1545-4304
Publication Date
January 6, 2017
Volume
57
Start / End Page
61 / 79
Location
United States
Related Subject Headings
- Vision Disorders
- SELEX Aptamer Technique
- Randomized Controlled Trials as Topic
- Pharmacology & Pharmacy
- Neoplasms
- Humans
- Aptamers, Nucleotide
- Animals
- 3214 Pharmacology and pharmaceutical sciences
- 11 Medical and Health Sciences
Citation
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Chicago
ICMJE
MLA
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Nimjee, S. M., White, R. R., Becker, R. C., & Sullenger, B. A. (2017). Aptamers as Therapeutics. Annu Rev Pharmacol Toxicol, 57, 61–79. https://doi.org/10.1146/annurev-pharmtox-010716-104558
Nimjee, Shahid M., Rebekah R. White, Richard C. Becker, and Bruce A. Sullenger. “Aptamers as Therapeutics.” Annu Rev Pharmacol Toxicol 57 (January 6, 2017): 61–79. https://doi.org/10.1146/annurev-pharmtox-010716-104558.
Nimjee SM, White RR, Becker RC, Sullenger BA. Aptamers as Therapeutics. Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:61–79.
Nimjee, Shahid M., et al. “Aptamers as Therapeutics.” Annu Rev Pharmacol Toxicol, vol. 57, Jan. 2017, pp. 61–79. Pubmed, doi:10.1146/annurev-pharmtox-010716-104558.
Nimjee SM, White RR, Becker RC, Sullenger BA. Aptamers as Therapeutics. Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:61–79.
Published In
Annu Rev Pharmacol Toxicol
DOI
EISSN
1545-4304
Publication Date
January 6, 2017
Volume
57
Start / End Page
61 / 79
Location
United States
Related Subject Headings
- Vision Disorders
- SELEX Aptamer Technique
- Randomized Controlled Trials as Topic
- Pharmacology & Pharmacy
- Neoplasms
- Humans
- Aptamers, Nucleotide
- Animals
- 3214 Pharmacology and pharmaceutical sciences
- 11 Medical and Health Sciences