VB4-845, a conjugated recombinant antibody and immunotoxin for head and neck cancer and bladder cancer.
Publication
, Journal Article
Biggers, K; Scheinfeld, N
Published in: Curr Opin Mol Ther
April 2008
Viventia Biotech Inc, under license from the University of Zurich, is developing VB4-845, comprising a Pseudomonas exotoxin fused to an anti-epithelial cell adhesion molecule single-chain antibody fragment, for the potential treatment of head and neck cancer (intratumoral) and bladder cancer (intravesical). VB4-845 is currently undergoing phase II and III clinical trials in patients with head and neck squamous cell carcinomas, as well as phase II clinical trials for the treatment of superficial transitional cell carcinoma of the bladder.
Duke Scholars
Published In
Curr Opin Mol Ther
ISSN
1464-8431
Publication Date
April 2008
Volume
10
Issue
2
Start / End Page
176 / 186
Location
England
Related Subject Headings
- Urinary Bladder Neoplasms
- Structure-Activity Relationship
- Recombinant Proteins
- Immunotoxins
- Humans
- Head and Neck Neoplasms
- Drug Evaluation, Preclinical
- Biotechnology
- Antineoplastic Agents
- Antibodies
Citation
APA
Chicago
ICMJE
MLA
NLM
Biggers, K., & Scheinfeld, N. (2008). VB4-845, a conjugated recombinant antibody and immunotoxin for head and neck cancer and bladder cancer. Curr Opin Mol Ther, 10(2), 176–186.
Biggers, Kristen, and Noah Scheinfeld. “VB4-845, a conjugated recombinant antibody and immunotoxin for head and neck cancer and bladder cancer.” Curr Opin Mol Ther 10, no. 2 (April 2008): 176–86.
Biggers K, Scheinfeld N. VB4-845, a conjugated recombinant antibody and immunotoxin for head and neck cancer and bladder cancer. Curr Opin Mol Ther. 2008 Apr;10(2):176–86.
Biggers, Kristen, and Noah Scheinfeld. “VB4-845, a conjugated recombinant antibody and immunotoxin for head and neck cancer and bladder cancer.” Curr Opin Mol Ther, vol. 10, no. 2, Apr. 2008, pp. 176–86.
Biggers K, Scheinfeld N. VB4-845, a conjugated recombinant antibody and immunotoxin for head and neck cancer and bladder cancer. Curr Opin Mol Ther. 2008 Apr;10(2):176–186.
Published In
Curr Opin Mol Ther
ISSN
1464-8431
Publication Date
April 2008
Volume
10
Issue
2
Start / End Page
176 / 186
Location
England
Related Subject Headings
- Urinary Bladder Neoplasms
- Structure-Activity Relationship
- Recombinant Proteins
- Immunotoxins
- Humans
- Head and Neck Neoplasms
- Drug Evaluation, Preclinical
- Biotechnology
- Antineoplastic Agents
- Antibodies