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Evidence of Microvascular Changes in the Retina following Kawasaki Disease.

Publication ,  Journal Article
Chen, KYH; Burgner, DP; Wong, TY; Saw, SM; Quek, SC; Pang, AYC; Leo, SW; Wong, IB; Zannino, D; Curtis, N; Cheung, M; Cheung, CY; Lim, TCW
Published in: Sci Rep
January 17, 2017

It is unclear whether all children with Kawasaki disease (KD) have increased later cardiovascular risk. The retinal microvasculature reflects changes in the microcirculation and is associated with traditional cardiovascular risk factors and events. The aim of this study was to investigate retinal microvascular parameters in two populations of patients with previous KD and control participants. We performed case-control studies of 116 (57 patients and 59 control participants) Australian and 156 (78 patients and 78 control participants) Singaporean individuals, at least two years since their acute illness. Standardised retinal photographs were graded by trained technicians using a semi-automated software, which quantifies the retinal microvasculature (calibre, branching angle, fractal dimensions, and tortuosity). Retinal venules of Singaporean KD patients were 9.67 μm (95% CI 4.87 to 14.51, p < 0.001) larger than control participants following correction for traditional cardiovascular risk factors. An incremental increase in the size of retinal venules in those with coronary artery abnormalities was observed. There was limited evidence that retinal venules were larger in Australian KD patients with coronary artery abnormalities compared to control participants (7.34 μm, 95% CI 1.30 to 15.99, p = 0.10). Differences in retinal microvasculature were particularly evident in Singaporean KD patients. Larger retinal venules may reflect chronic inflammation and endothelial dysfunction, and are associated with coronary artery disease in adults.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 17, 2017

Volume

7

Start / End Page

40513

Location

England

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Retinal Vessels
  • Retina
  • Mucocutaneous Lymph Node Syndrome
  • Male
  • Humans
  • Female
  • Child
  • Case-Control Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chen, K. Y. H., Burgner, D. P., Wong, T. Y., Saw, S. M., Quek, S. C., Pang, A. Y. C., … Lim, T. C. W. (2017). Evidence of Microvascular Changes in the Retina following Kawasaki Disease. Sci Rep, 7, 40513. https://doi.org/10.1038/srep40513
Chen, Katherine Y. H., David P. Burgner, Tien Y. Wong, Seang Mei Saw, Swee Chye Quek, Audrey Y. C. Pang, Seo Wei Leo, et al. “Evidence of Microvascular Changes in the Retina following Kawasaki Disease.Sci Rep 7 (January 17, 2017): 40513. https://doi.org/10.1038/srep40513.
Chen KYH, Burgner DP, Wong TY, Saw SM, Quek SC, Pang AYC, et al. Evidence of Microvascular Changes in the Retina following Kawasaki Disease. Sci Rep. 2017 Jan 17;7:40513.
Chen, Katherine Y. H., et al. “Evidence of Microvascular Changes in the Retina following Kawasaki Disease.Sci Rep, vol. 7, Jan. 2017, p. 40513. Pubmed, doi:10.1038/srep40513.
Chen KYH, Burgner DP, Wong TY, Saw SM, Quek SC, Pang AYC, Leo SW, Wong IB, Zannino D, Curtis N, Cheung M, Cheung CY, Lim TCW. Evidence of Microvascular Changes in the Retina following Kawasaki Disease. Sci Rep. 2017 Jan 17;7:40513.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 17, 2017

Volume

7

Start / End Page

40513

Location

England

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Retinal Vessels
  • Retina
  • Mucocutaneous Lymph Node Syndrome
  • Male
  • Humans
  • Female
  • Child
  • Case-Control Studies