Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Multiple markers of inflammation and weight status: cross-sectional analyses throughout childhood.

Publication ,  Journal Article
Skinner, AC; Steiner, MJ; Henderson, FW; Perrin, EM
Published in: Pediatrics
April 2010

OBJECTIVE: Inflammatory markers such as C-reactive protein (CRP) are related to obesity in adults, but the association is less clear in children. Our objective was to examine relationships between multiple markers of inflammation and children's weight status; we hypothesized that the prevalence of inflammatory markers would increase as weight status increased. METHODS: We conducted a cross-sectional analysis of children in the United States aged 1 to 17 years in the National Health and Nutrition Examination Survey, 1999-2006. Children were categorized using weight-for-length when age <2 years and BMI for > or =2 years, as very obese (> or =99th percentile), obese (<99th and > or =95th percentile), overweight (<95th and > or =85th percentile), and healthy weight (>5th to < or =85th percentile) according to expert consensus. Our main outcome measures were high-sensitivity CRP and absolute neutrophil count, in addition to a novel third measure: ferritin controlled for iron status using a ferritin/transferrin ratio. We used Cox proportional hazards models to examine risk of abnormal values of inflammatory markers according to weight. RESULTS: Increased risk of a CRP level of >1.0 mg/L was evident among very obese children from ages 3 to 5 years (hazard ratio [HR]: 2.29; P < .01) through 15 to 17 years (HR: 4.73; P < .01). Increased risk of abnormal neutrophil count among very obese children began at 6 to 8 years (HR: 2.00; P = .049), and increased prevalence of abnormal ferritin/transferrin ratio began at 9 to 11 years (HR: 7.06; P < .001). CONCLUSIONS: Multiple inflammatory markers are strongly and positively associated with increasing weight status in children, and this relationship starts as young as age 3. Elevated inflammatory markers in very young obese children are particularly concerning, because inflammation may cause long-term, cumulative vascular damage. This deserves additional research via longitudinal design.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

April 2010

Volume

125

Issue

4

Start / End Page

e801 / e809

Location

United States

Related Subject Headings

  • Weight Gain
  • Pediatrics
  • Overweight
  • Obesity
  • Neutrophils
  • Male
  • Inflammation Mediators
  • Infant
  • Humans
  • Health Surveys
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Skinner, A. C., Steiner, M. J., Henderson, F. W., & Perrin, E. M. (2010). Multiple markers of inflammation and weight status: cross-sectional analyses throughout childhood. Pediatrics, 125(4), e801–e809. https://doi.org/10.1542/peds.2009-2182
Skinner, Asheley Cockrell, Michael J. Steiner, Frederick W. Henderson, and Eliana M. Perrin. “Multiple markers of inflammation and weight status: cross-sectional analyses throughout childhood.Pediatrics 125, no. 4 (April 2010): e801–9. https://doi.org/10.1542/peds.2009-2182.
Skinner AC, Steiner MJ, Henderson FW, Perrin EM. Multiple markers of inflammation and weight status: cross-sectional analyses throughout childhood. Pediatrics. 2010 Apr;125(4):e801–9.
Skinner, Asheley Cockrell, et al. “Multiple markers of inflammation and weight status: cross-sectional analyses throughout childhood.Pediatrics, vol. 125, no. 4, Apr. 2010, pp. e801–09. Pubmed, doi:10.1542/peds.2009-2182.
Skinner AC, Steiner MJ, Henderson FW, Perrin EM. Multiple markers of inflammation and weight status: cross-sectional analyses throughout childhood. Pediatrics. 2010 Apr;125(4):e801–e809.

Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

April 2010

Volume

125

Issue

4

Start / End Page

e801 / e809

Location

United States

Related Subject Headings

  • Weight Gain
  • Pediatrics
  • Overweight
  • Obesity
  • Neutrophils
  • Male
  • Inflammation Mediators
  • Infant
  • Humans
  • Health Surveys