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Characterization of Death in Neonatal Encephalopathy in the Hypothermia Era.

Publication ,  Journal Article
Lemmon, ME; Boss, RD; Bonifacio, SL; Foster-Barber, A; Barkovich, AJ; Glass, HC
Published in: J Child Neurol
March 2017

This study aimed to characterize the circumstances of death in encephalopathic neonates treated with therapeutic hypothermia. Patients who died after or during treatment with therapeutic hypothermia between 2007-2014 were identified. Patient circumstance of death was characterized using an established paradigm. Thirty-one of 229 patients died (14%) at a median of 3 days of life. Most who died were severely encephalopathic on examination (90%) and had severely abnormal electroencephalographic (EEG) findings (87%). All those who had magnetic resonance images (n = 13) had evidence of moderate-severe brain injury; 6 had near-total brain injury. Cooling was discontinued prematurely in 61% of patients. Most patients (90%) were physiologically stable at the time of death; 81% died following elective extubation for quality of life considerations. Three patients (10%) died following withholding or removal of artificial hydration and nutrition. Characterization of death in additional cohorts is needed to identify differences in decision making practices over time and between centers.

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Published In

J Child Neurol

DOI

EISSN

1708-8283

Publication Date

March 2017

Volume

32

Issue

4

Start / End Page

360 / 365

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Failure
  • Prospective Studies
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Intensive Care Units, Neonatal
  • Infant
  • Hypothermia, Induced
  • Humans
 

Citation

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Chicago
ICMJE
MLA
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Lemmon, M. E., Boss, R. D., Bonifacio, S. L., Foster-Barber, A., Barkovich, A. J., & Glass, H. C. (2017). Characterization of Death in Neonatal Encephalopathy in the Hypothermia Era. J Child Neurol, 32(4), 360–365. https://doi.org/10.1177/0883073816681904
Lemmon, Monica E., Renee D. Boss, Sonia L. Bonifacio, Audrey Foster-Barber, A James Barkovich, and Hannah C. Glass. “Characterization of Death in Neonatal Encephalopathy in the Hypothermia Era.J Child Neurol 32, no. 4 (March 2017): 360–65. https://doi.org/10.1177/0883073816681904.
Lemmon ME, Boss RD, Bonifacio SL, Foster-Barber A, Barkovich AJ, Glass HC. Characterization of Death in Neonatal Encephalopathy in the Hypothermia Era. J Child Neurol. 2017 Mar;32(4):360–5.
Lemmon, Monica E., et al. “Characterization of Death in Neonatal Encephalopathy in the Hypothermia Era.J Child Neurol, vol. 32, no. 4, Mar. 2017, pp. 360–65. Pubmed, doi:10.1177/0883073816681904.
Lemmon ME, Boss RD, Bonifacio SL, Foster-Barber A, Barkovich AJ, Glass HC. Characterization of Death in Neonatal Encephalopathy in the Hypothermia Era. J Child Neurol. 2017 Mar;32(4):360–365.
Journal cover image

Published In

J Child Neurol

DOI

EISSN

1708-8283

Publication Date

March 2017

Volume

32

Issue

4

Start / End Page

360 / 365

Location

United States

Related Subject Headings

  • Young Adult
  • Treatment Failure
  • Prospective Studies
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Intensive Care Units, Neonatal
  • Infant
  • Hypothermia, Induced
  • Humans