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Transcriptional regulation of matrix gla protein.

Publication ,  Journal Article
Farzaneh-Far, A; Weissberg, PL; Proudfoot, D; Shanahan, CM
Published in: Z Kardiol
2001
Published version (DOI) Link to item

Matrix Gla Protein (MGP) is a small protein which is thought to be an inhibitor of tissue calcification and a regulator of cell differentiation. In this study we have examined the transcriptional regulation of MGP within rat vascular smooth muscle cells (VSMCs). We found that MGP transcription is downregulated by retinoic acid and transforming growth factor beta (TGF beta) whereas it is upregulated by vitamin D3 and cyclic AMP.

Duke Scholars

Afshin Farzaneh-Far
Author Afshin Farzaneh-Far Medicine, Cardiology
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Published In

Z Kardiol

DOI

10.1007/s003920170040

ISSN

0300-5860

Publication Date

2001

Volume

90 Suppl 3

Start / End Page

38 / 42

Location

Germany

Related Subject Headings

  • Up-Regulation
  • Tretinoin
  • Transforming Growth Factor beta
  • Transcription, Genetic
  • Rats
  • Muscle, Smooth, Vascular
  • Humans
  • Gene Expression Regulation
  • Extracellular Matrix Proteins
  • Down-Regulation
 

Citation

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Farzaneh-Far, A., Weissberg, P. L., Proudfoot, D., & Shanahan, C. M. (2001). Transcriptional regulation of matrix gla protein. Z Kardiol, 90 Suppl 3, 38–42. https://doi.org/10.1007/s003920170040
Farzaneh-Far, A., P. L. Weissberg, D. Proudfoot, and C. M. Shanahan. “Transcriptional regulation of matrix gla protein.” Z Kardiol 90 Suppl 3 (2001): 38–42. https://doi.org/10.1007/s003920170040.
Farzaneh-Far A, Weissberg PL, Proudfoot D, Shanahan CM. Transcriptional regulation of matrix gla protein. Z Kardiol. 2001;90 Suppl 3:38–42.
Farzaneh-Far, A., et al. “Transcriptional regulation of matrix gla protein.” Z Kardiol, vol. 90 Suppl 3, 2001, pp. 38–42. Pubmed, doi:10.1007/s003920170040.
Farzaneh-Far A, Weissberg PL, Proudfoot D, Shanahan CM. Transcriptional regulation of matrix gla protein. Z Kardiol. 2001;90 Suppl 3:38–42.

Published In

Z Kardiol

DOI

10.1007/s003920170040

ISSN

0300-5860

Publication Date

2001

Volume

90 Suppl 3

Start / End Page

38 / 42

Location

Germany

Related Subject Headings

  • Up-Regulation
  • Tretinoin
  • Transforming Growth Factor beta
  • Transcription, Genetic
  • Rats
  • Muscle, Smooth, Vascular
  • Humans
  • Gene Expression Regulation
  • Extracellular Matrix Proteins
  • Down-Regulation