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The role of apoptosis in the initiation of vascular calcification.

Publication ,  Journal Article
Proudfoot, D; Skepper, JN; Hegyi, L; Farzaneh-Far, A; Shanahan, CM; Weissberg, PL
Published in: Z Kardiol
2001

The initiation sites for calcification in cartilage and bone are cellular products called matrix vesicles. Similar structures have been found in calcified arteries and recent studies suggest that these may be derived from apoptotic cells. It is well established that there is a link between cell death and calcification but the mechanism involved is not known. Since apoptotic cell death is known to occur in the vasculature, we set out to investigate the role of apoptosis in the initiation of vascular calcification. We used a human vascular calcification model in which postconfluent vascular smooth muscle cell (VSMC) cultures form nodules spontaneously and calcify after approximately 28 days. Our studies revealed that apoptosis occurred prior to the onset of calcification and that VSMC "blebs" or apoptotic bodies (ABs) could concentrate calcium in a crystallised form. These observations suggest that apoptosis is involved in the development of VSMC calcification and that VSMC-derived ABs have similarities with matrix vesicles.

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Published In

Z Kardiol

DOI

ISSN

0300-5860

Publication Date

2001

Volume

90 Suppl 3

Start / End Page

43 / 46

Location

Germany

Related Subject Headings

  • Muscle, Smooth, Vascular
  • Inclusion Bodies
  • Humans
  • Crystallization
  • Cells, Cultured
  • Cardiovascular System & Hematology
  • Calcium
  • Calcinosis
  • Arteriosclerosis
  • Apoptosis
 

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Proudfoot, D., Skepper, J. N., Hegyi, L., Farzaneh-Far, A., Shanahan, C. M., & Weissberg, P. L. (2001). The role of apoptosis in the initiation of vascular calcification. Z Kardiol, 90 Suppl 3, 43–46. https://doi.org/10.1007/s003920170041
Proudfoot, D., J. N. Skepper, L. Hegyi, A. Farzaneh-Far, C. M. Shanahan, and P. L. Weissberg. “The role of apoptosis in the initiation of vascular calcification.Z Kardiol 90 Suppl 3 (2001): 43–46. https://doi.org/10.1007/s003920170041.
Proudfoot D, Skepper JN, Hegyi L, Farzaneh-Far A, Shanahan CM, Weissberg PL. The role of apoptosis in the initiation of vascular calcification. Z Kardiol. 2001;90 Suppl 3:43–6.
Proudfoot, D., et al. “The role of apoptosis in the initiation of vascular calcification.Z Kardiol, vol. 90 Suppl 3, 2001, pp. 43–46. Pubmed, doi:10.1007/s003920170041.
Proudfoot D, Skepper JN, Hegyi L, Farzaneh-Far A, Shanahan CM, Weissberg PL. The role of apoptosis in the initiation of vascular calcification. Z Kardiol. 2001;90 Suppl 3:43–46.

Published In

Z Kardiol

DOI

ISSN

0300-5860

Publication Date

2001

Volume

90 Suppl 3

Start / End Page

43 / 46

Location

Germany

Related Subject Headings

  • Muscle, Smooth, Vascular
  • Inclusion Bodies
  • Humans
  • Crystallization
  • Cells, Cultured
  • Cardiovascular System & Hematology
  • Calcium
  • Calcinosis
  • Arteriosclerosis
  • Apoptosis