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Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity.

Publication ,  Journal Article
Ogawa, M; Tomita, Y; Nakamura, Y; Lee, M-J; Lee, S; Tomita, S; Nagaya, T; Sato, K; Yamauchi, T; Iwai, H; Kumar, A; Haystead, T; Shroff, H ...
Published in: Oncotarget
February 7, 2017

Immunogenic cell death (ICD) is a form of cell death that activates an adaptive immune response against dead-cell-associated antigens. Cancer cells killed via ICD can elicit antitumor immunity. ICD is efficiently induced by near-infrared photo-immunotherapy (NIR-PIT) that selectively kills target-cells on which antibody-photoabsorber conjugates bind and are activated by NIR light exposure. Advanced live cell microscopies showed that NIR-PIT caused rapid and irreversible damage to the cell membrane function leading to swelling and bursting, releasing intracellular components due to the influx of water into the cell. The process also induces relocation of ICD bio markers including calreticulin, Hsp70 and Hsp90 to the cell surface and the rapid release of immunogenic signals including ATP and HMGB1 followed by maturation of immature dendritic cells. Thus, NIR-PIT is a therapy that kills tumor cells by ICD, eliciting a host immune response against tumor.

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Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

February 7, 2017

Volume

8

Issue

6

Start / End Page

10425 / 10436

Location

United States

Related Subject Headings

  • Xenograft Model Antitumor Assays
  • Tumor Escape
  • Trastuzumab
  • Transfection
  • Time Factors
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Phototherapy
  • Photosensitizing Agents
  • Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
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Ogawa, M., Tomita, Y., Nakamura, Y., Lee, M.-J., Lee, S., Tomita, S., … Kobayashi, H. (2017). Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity. Oncotarget, 8(6), 10425–10436. https://doi.org/10.18632/oncotarget.14425
Ogawa, Mikako, Yusuke Tomita, Yuko Nakamura, Min-Jung Lee, Sunmin Lee, Saori Tomita, Tadanobu Nagaya, et al. “Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity.Oncotarget 8, no. 6 (February 7, 2017): 10425–36. https://doi.org/10.18632/oncotarget.14425.
Ogawa M, Tomita Y, Nakamura Y, Lee M-J, Lee S, Tomita S, et al. Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity. Oncotarget. 2017 Feb 7;8(6):10425–36.
Ogawa, Mikako, et al. “Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity.Oncotarget, vol. 8, no. 6, Feb. 2017, pp. 10425–36. Pubmed, doi:10.18632/oncotarget.14425.
Ogawa M, Tomita Y, Nakamura Y, Lee M-J, Lee S, Tomita S, Nagaya T, Sato K, Yamauchi T, Iwai H, Kumar A, Haystead T, Shroff H, Choyke PL, Trepel JB, Kobayashi H. Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity. Oncotarget. 2017 Feb 7;8(6):10425–10436.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

February 7, 2017

Volume

8

Issue

6

Start / End Page

10425 / 10436

Location

United States

Related Subject Headings

  • Xenograft Model Antitumor Assays
  • Tumor Escape
  • Trastuzumab
  • Transfection
  • Time Factors
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Phototherapy
  • Photosensitizing Agents
  • Neoplasms