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Interaction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population.

Publication ,  Journal Article
Ke, T; Dorajoo, R; Han, Y; Khor, C-C; van Dam, RM; Yuan, J-M; Koh, W-P; Liu, J; Teo, YY; Goh, DYT; Tai, ES; Wong, TY; Cheng, C-Y; Heng, C-K ...
Published in: Ann Hum Genet
September 2016

Peroxisome proliferator activated receptors (PPARs) are transcription factors involved in the regulation of key metabolic pathways. Numerous in vivo and in vitro studies have established their important roles in lipid metabolism. A few SNPs in PPAR genes have been reported to be associated with lipid levels. In this study, we aimed to investigate the interactive effects between single nucleotide polymorphisms (SNPs) in three PPAR isoforms α/δ/γ and other genetic variants across the genome on plasma high-density lipoprotein-cholesterol (HDL-C) levels. Study subjects (N = 2003) were genotyped using Illumina HumanOmniZhongHua-8 Beadchip. Fifty-three tag SNPs ± 100 kb of PPAR α, δ, and γ (r(2) < 0.2) were selected. The effect of interactions between PPAR SNPs and those across the genome on HDL-C was tested using linear regression models. One statistically significant interaction influencing HDL-C was detected between PPARδ SNP rs2267668 and epithelial membrane protein 2 (EMP2) downstream SNP rs7191411 (N = 1993, β = 0.74, adjusted P = 0.022). This interaction was successfully replicated in the meta-analysis of two additional Chinese cohorts (N = 3948, P = 0.01). The present study showed a novel SNP × SNP interaction between rs2267668 in PPARδ and rs7191411 in EMP2 that has significant impact on circulating HDL-C levels in the Singaporean Chinese population.

Duke Scholars

Published In

Ann Hum Genet

DOI

EISSN

1469-1809

Publication Date

September 2016

Volume

80

Issue

5

Start / End Page

282 / 293

Location

England

Related Subject Headings

  • Singapore
  • Prospective Studies
  • Polymorphism, Single Nucleotide
  • PPAR delta
  • Middle Aged
  • Membrane Glycoproteins
  • Male
  • Linkage Disequilibrium
  • Humans
  • Genetics & Heredity
 

Citation

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Chicago
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Ke, T., Dorajoo, R., Han, Y., Khor, C.-C., van Dam, R. M., Yuan, J.-M., … Heng, C.-K. (2016). Interaction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population. Ann Hum Genet, 80(5), 282–293. https://doi.org/10.1111/ahg.12164
Ke, Tingjing, Rajkumar Dorajoo, Yi Han, Chiea-Chuen Khor, Rob M. van Dam, Jian-Min Yuan, Woon-Puay Koh, et al. “Interaction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population.Ann Hum Genet 80, no. 5 (September 2016): 282–93. https://doi.org/10.1111/ahg.12164.
Ke, Tingjing, et al. “Interaction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population.Ann Hum Genet, vol. 80, no. 5, Sept. 2016, pp. 282–93. Pubmed, doi:10.1111/ahg.12164.
Ke T, Dorajoo R, Han Y, Khor C-C, van Dam RM, Yuan J-M, Koh W-P, Liu J, Teo YY, Goh DYT, Tai ES, Wong TY, Cheng C-Y, Friedlander Y, Heng C-K. Interaction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population. Ann Hum Genet. 2016 Sep;80(5):282–293.
Journal cover image

Published In

Ann Hum Genet

DOI

EISSN

1469-1809

Publication Date

September 2016

Volume

80

Issue

5

Start / End Page

282 / 293

Location

England

Related Subject Headings

  • Singapore
  • Prospective Studies
  • Polymorphism, Single Nucleotide
  • PPAR delta
  • Middle Aged
  • Membrane Glycoproteins
  • Male
  • Linkage Disequilibrium
  • Humans
  • Genetics & Heredity