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Choroidal Structural Changes in Myopic Choroidal Neovascularization After Treatment With Antivascular Endothelial Growth Factor Over 1 Year.

Publication ,  Journal Article
Ng, WY; Ting, DSW; Agrawal, R; Khandelwal, N; Htoon, HM; Lee, SY; Wong, TY; Cheung, GCM
Published in: Invest Ophthalmol Vis Sci
September 1, 2016

PURPOSE: To evaluate choroidal structural changes in eyes with myopic choroidal neovascularization (mCNV) treated with anti-VEGF over 12 months. METHODS: We prospectively evaluated subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) using spectral-domain optical coherence tomography (SD-OCT) at baseline, 6, and 12 months in both eyes in patients presenting with unilateral mCNV. Choroidal vascularity index was defined as the ratio of luminal area to total choroidal area after SD-OCT images were binarized digitally. RESULTS: We included 20 patients (20 eyes with mCNV and 20 fellow eyes without mCNV) with mean age of 60.35 ± 10.85 years. At baseline, mean SFCT and CVI was similar between eyes with mCNV and fellow eyes (69.20 ± 63.04 μm vs. 67.10 ± 65.74 μm, P = 0.713 for SFCT and 59.44 ± 3.92% vs. 59.03 ±. 5.58%, P = 0.958 for CVI). Subfoveal choroidal thickness decreased significantly in the mCNV eyes to 54.75 ± 45.43 μm (P = 0.017) at 12 months after anti-VEGF therapy, whereas SFCT in the contralateral eyes did not change significantly. There was no significant change in CVI in mCNV eyes or contralateral eyes from baseline to 12 months. Thinning of SFCT did not influence final BCVA. CONCLUSIONS: Thinning of subfoveal choroid without alteration in CVI was observed in eyes with mCNV treated with anti-VEGF therapy over 12 months. This finding may be explained by mechanical stretching in response to globe expansion.

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Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

September 1, 2016

Volume

57

Issue

11

Start / End Page

4933 / 4939

Location

United States

Related Subject Headings

  • Ophthalmology & Optometry
  • 3212 Ophthalmology and optometry
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

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Ng, W. Y., Ting, D. S. W., Agrawal, R., Khandelwal, N., Htoon, H. M., Lee, S. Y., … Cheung, G. C. M. (2016). Choroidal Structural Changes in Myopic Choroidal Neovascularization After Treatment With Antivascular Endothelial Growth Factor Over 1 Year. Invest Ophthalmol Vis Sci, 57(11), 4933–4939. https://doi.org/10.1167/iovs.16-20191
Ng, Wei Yan, Daniel Shu Wei Ting, Rupesh Agrawal, Neha Khandelwal, Hla Myint Htoon, Shu Yen Lee, Tien Yin Wong, and Gemmy Chui Ming Cheung. “Choroidal Structural Changes in Myopic Choroidal Neovascularization After Treatment With Antivascular Endothelial Growth Factor Over 1 Year.Invest Ophthalmol Vis Sci 57, no. 11 (September 1, 2016): 4933–39. https://doi.org/10.1167/iovs.16-20191.
Ng WY, Ting DSW, Agrawal R, Khandelwal N, Htoon HM, Lee SY, et al. Choroidal Structural Changes in Myopic Choroidal Neovascularization After Treatment With Antivascular Endothelial Growth Factor Over 1 Year. Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4933–9.
Ng, Wei Yan, et al. “Choroidal Structural Changes in Myopic Choroidal Neovascularization After Treatment With Antivascular Endothelial Growth Factor Over 1 Year.Invest Ophthalmol Vis Sci, vol. 57, no. 11, Sept. 2016, pp. 4933–39. Pubmed, doi:10.1167/iovs.16-20191.
Ng WY, Ting DSW, Agrawal R, Khandelwal N, Htoon HM, Lee SY, Wong TY, Cheung GCM. Choroidal Structural Changes in Myopic Choroidal Neovascularization After Treatment With Antivascular Endothelial Growth Factor Over 1 Year. Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4933–4939.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

September 1, 2016

Volume

57

Issue

11

Start / End Page

4933 / 4939

Location

United States

Related Subject Headings

  • Ophthalmology & Optometry
  • 3212 Ophthalmology and optometry
  • 11 Medical and Health Sciences
  • 06 Biological Sciences