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Age of onset of myopia predicts risk of high myopia in later childhood in myopic Singapore children.

Publication ,  Journal Article
Chua, SYL; Sabanayagam, C; Cheung, Y-B; Chia, A; Valenzuela, RK; Tan, D; Wong, T-Y; Cheng, C-Y; Saw, S-M
Published in: Ophthalmic Physiol Opt
July 2016

PURPOSE: To investigate the effect of age of myopia onset on the severity of myopia later in life among myopic children. METHODS: In this prospective study, school children aged 7-9 years from the Singapore Cohort Of the Risk factors for Myopia (SCORM) were followed up till 11 years (n = 928). Age of myopia onset was defined either through questionnaire at baseline (age 7-9 years) or subsequent annual follow-up visits. Age of onset of myopia was a surrogate indicator of duration of myopia progression till age 11 years. Cycloplegic refraction and axial length were measured at every annual eye examination. High myopia was defined as spherical equivalent of ≤-5.0 D. A questionnaire determined the other risk factors. RESULTS: In multivariable regression models, younger age of myopia onset (per year decrease) or longer duration of myopia progression was associated with high myopia (odds ratio (OR) = 2.86; 95% CI: 2.39 to 3.43), more myopic spherical equivalent (regression coefficient (β) = -0.86 D; 95% CI: -0.93 to -0.80) and longer axial length (β = 0.28 mm; 95% CI: 0.24 to 0.32) at aged 11 years, after adjusting for gender, race, school, books per week and parental myopia. In Receiver Operating Curve (ROC) analyses, age of myopia onset alone predicted high myopia by 85% (area under the curve = 0.85), while the addition of other factors including gender, race, school, books per week and parental myopia only marginally improved this prediction (area under the curve = 0.87). CONCLUSIONS: Age of myopia onset or duration of myopia progression was the most important predictor of high myopia in later childhood in myopic children. Future trials to retard the progression of myopia to high myopia could focus on children with younger age of myopia onset or with longer duration of myopia progression.

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Published In

Ophthalmic Physiol Opt

DOI

EISSN

1475-1313

Publication Date

July 2016

Volume

36

Issue

4

Start / End Page

388 / 394

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Singapore
  • Severity of Illness Index
  • Risk Factors
  • Refraction, Ocular
  • Prospective Studies
  • Prognosis
  • Prevalence
  • Ophthalmology & Optometry
  • Odds Ratio
 

Citation

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ICMJE
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Chua, S. Y. L., Sabanayagam, C., Cheung, Y.-B., Chia, A., Valenzuela, R. K., Tan, D., … Saw, S.-M. (2016). Age of onset of myopia predicts risk of high myopia in later childhood in myopic Singapore children. Ophthalmic Physiol Opt, 36(4), 388–394. https://doi.org/10.1111/opo.12305
Chua, Sharon Y. L., Charumathi Sabanayagam, Yin-Bun Cheung, Audrey Chia, Robert K. Valenzuela, Donald Tan, Tien-Yin Wong, Ching-Yu Cheng, and Seang-Mei Saw. “Age of onset of myopia predicts risk of high myopia in later childhood in myopic Singapore children.Ophthalmic Physiol Opt 36, no. 4 (July 2016): 388–94. https://doi.org/10.1111/opo.12305.
Chua SYL, Sabanayagam C, Cheung Y-B, Chia A, Valenzuela RK, Tan D, et al. Age of onset of myopia predicts risk of high myopia in later childhood in myopic Singapore children. Ophthalmic Physiol Opt. 2016 Jul;36(4):388–94.
Chua, Sharon Y. L., et al. “Age of onset of myopia predicts risk of high myopia in later childhood in myopic Singapore children.Ophthalmic Physiol Opt, vol. 36, no. 4, July 2016, pp. 388–94. Pubmed, doi:10.1111/opo.12305.
Chua SYL, Sabanayagam C, Cheung Y-B, Chia A, Valenzuela RK, Tan D, Wong T-Y, Cheng C-Y, Saw S-M. Age of onset of myopia predicts risk of high myopia in later childhood in myopic Singapore children. Ophthalmic Physiol Opt. 2016 Jul;36(4):388–394.
Journal cover image

Published In

Ophthalmic Physiol Opt

DOI

EISSN

1475-1313

Publication Date

July 2016

Volume

36

Issue

4

Start / End Page

388 / 394

Location

England

Related Subject Headings

  • Surveys and Questionnaires
  • Singapore
  • Severity of Illness Index
  • Risk Factors
  • Refraction, Ocular
  • Prospective Studies
  • Prognosis
  • Prevalence
  • Ophthalmology & Optometry
  • Odds Ratio