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Validation of the Total Cerebrovascular Disease Burden Scale in a Community Sample.

Publication ,  Journal Article
Xu, X; Hilal, S; Collinson, SL; Chan, QL; Yi Chong, EJ; Ikram, MK; Venketasubramanian, N; Cheng, C-Y; Wong, TY; Chen, CL-H
Published in: J Alzheimers Dis
April 12, 2016

BACKGROUND: A total cerebrovascular disease (CeVD) burden scale was previously constructed and an inverse association of CeVD burden and cognition was found. However, the generalizability of the CeVD scale has not been examined. OBJECTIVE: The objective was to validate the previously constructed total CeVD burden scale by establishing its association with cognitive function and dementia diagnosis in a community sample. METHODS: Eligible participants were assessed on an extensive neuropsychological battery and underwent MRI scans. The total CeVD scale, comprising markers of both small- and large-vessel diseases, was derived according to previously described criteria. Association of total CeVD burden with global and domain-based cognitive performance and dementia diagnostic utility of the scale was established. RESULTS: A total of 863 participants were included in the analysis. A stepwise association of CeVD burden score with global and domain-specific cognitive function was found. Per score increase on the total CeVD burden scale was associated with 3.6 (95% CI = 2.1-6.4) times higher odds of dementia compared to dementia-free. DISCUSSION: The total CeVD burden scale is associated with cognition and dementia in a community sample. Longitudinal studies are required to establish the predictive ability of this scale.

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Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

April 12, 2016

Volume

52

Issue

3

Start / End Page

1021 / 1028

Location

Netherlands

Related Subject Headings

  • Singapore
  • Sampling Studies
  • Reproducibility of Results
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Neuroimaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Independent Living
 

Citation

APA
Chicago
ICMJE
MLA
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Xu, X., Hilal, S., Collinson, S. L., Chan, Q. L., Yi Chong, E. J., Ikram, M. K., … Chen, C.-H. (2016). Validation of the Total Cerebrovascular Disease Burden Scale in a Community Sample. J Alzheimers Dis, 52(3), 1021–1028. https://doi.org/10.3233/JAD-160139
Xu, Xin, Saima Hilal, Simon L. Collinson, Qun Lin Chan, Eddie Jun Yi Chong, Mohammad Kamran Ikram, Narayanaswamy Venketasubramanian, Ching-Yu Cheng, Tien Yin Wong, and Christopher Li-Hsian Chen. “Validation of the Total Cerebrovascular Disease Burden Scale in a Community Sample.J Alzheimers Dis 52, no. 3 (April 12, 2016): 1021–28. https://doi.org/10.3233/JAD-160139.
Xu X, Hilal S, Collinson SL, Chan QL, Yi Chong EJ, Ikram MK, et al. Validation of the Total Cerebrovascular Disease Burden Scale in a Community Sample. J Alzheimers Dis. 2016 Apr 12;52(3):1021–8.
Xu, Xin, et al. “Validation of the Total Cerebrovascular Disease Burden Scale in a Community Sample.J Alzheimers Dis, vol. 52, no. 3, Apr. 2016, pp. 1021–28. Pubmed, doi:10.3233/JAD-160139.
Xu X, Hilal S, Collinson SL, Chan QL, Yi Chong EJ, Ikram MK, Venketasubramanian N, Cheng C-Y, Wong TY, Chen CL-H. Validation of the Total Cerebrovascular Disease Burden Scale in a Community Sample. J Alzheimers Dis. 2016 Apr 12;52(3):1021–1028.

Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

April 12, 2016

Volume

52

Issue

3

Start / End Page

1021 / 1028

Location

Netherlands

Related Subject Headings

  • Singapore
  • Sampling Studies
  • Reproducibility of Results
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Neuroimaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Independent Living