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Subcortical Atrophy in Cognitive Impairment and Dementia.

Publication ,  Journal Article
Hilal, S; Amin, SM; Venketasubramanian, N; Niessen, WJ; Vrooman, H; Wong, TY; Chen, C; Ikram, MK
Published in: J Alzheimers Dis
2015

BACKGROUND: Cortical atrophy is a key neuroimaging feature of dementia. However, the role of subcortical gray matter reduction in cognitive impairment has not been explored extensively. OBJECTIVES: We examined the risk factors of subcortical structures on neuroimaging and their association with cognitive impairment and dementia. METHODS: Data from two studies were used: a subsample from the Epidemiology of Dementia in Singapore (EDIS) study of non-demented community-dwelling subjects (n = 550) and a case-control study. Subjects underwent similar neuropsychological tests and brain MRI. Subcortical volumes of accumbens, amygdala, caudate, pallidum, putamen, thalamus, hippocampus, and brainstem were measured. Cognitive impairment no dementia (CIND), dementia and its subtypes, vascular cognitive impairment (VCI), were defined using accepted criteria. Cognitive function was also expressed as both composite and domain-specific Z-scores. RESULTS: In the EDIS study, age, female gender, Malay ethnicity, diabetes, lacunar-infarcts, and white matter lesions were the most important risk factors for subcortical atrophy. Moreover, smaller volumes of accumbens, amygdala, caudate, thalamus, and brainstem were significantly associated with lower cognitive composite Z-scores. With respect to clinical outcomes in the case-control study, structures such as the accumbens, caudate, putamen, and hippocampus were associated with both CIND and dementia. Smaller caudate and pallidum volumes were related to VCI whereas amygdalar atrophy was only associated with non-VCI. Furthermore, subcortical atrophy was related to both VCI and non-VCI. CONCLUSION: Subcortical gray matter atrophy is not only observed in dementia, but also in the preclinical stages of cognitive impairment. Furthermore, besides VCI, subcortical structures were also related to non-VCI.

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Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

2015

Volume

48

Issue

3

Start / End Page

813 / 823

Location

Netherlands

Related Subject Headings

  • Singapore
  • Risk Factors
  • Prodromal Symptoms
  • Organ Size
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Gray Matter
 

Citation

APA
Chicago
ICMJE
MLA
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Hilal, S., Amin, S. M., Venketasubramanian, N., Niessen, W. J., Vrooman, H., Wong, T. Y., … Ikram, M. K. (2015). Subcortical Atrophy in Cognitive Impairment and Dementia. J Alzheimers Dis, 48(3), 813–823. https://doi.org/10.3233/JAD-150473
Hilal, Saima, Shaik Muhammad Amin, Narayanaswamy Venketasubramanian, Wiro J. Niessen, Henri Vrooman, Tien Yin Wong, Christopher Chen, and Mohammad Kamran Ikram. “Subcortical Atrophy in Cognitive Impairment and Dementia.J Alzheimers Dis 48, no. 3 (2015): 813–23. https://doi.org/10.3233/JAD-150473.
Hilal S, Amin SM, Venketasubramanian N, Niessen WJ, Vrooman H, Wong TY, et al. Subcortical Atrophy in Cognitive Impairment and Dementia. J Alzheimers Dis. 2015;48(3):813–23.
Hilal, Saima, et al. “Subcortical Atrophy in Cognitive Impairment and Dementia.J Alzheimers Dis, vol. 48, no. 3, 2015, pp. 813–23. Pubmed, doi:10.3233/JAD-150473.
Hilal S, Amin SM, Venketasubramanian N, Niessen WJ, Vrooman H, Wong TY, Chen C, Ikram MK. Subcortical Atrophy in Cognitive Impairment and Dementia. J Alzheimers Dis. 2015;48(3):813–823.

Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

2015

Volume

48

Issue

3

Start / End Page

813 / 823

Location

Netherlands

Related Subject Headings

  • Singapore
  • Risk Factors
  • Prodromal Symptoms
  • Organ Size
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Gray Matter