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Exposure to Atomic Bomb Radiation and Age-Related Macular Degeneration in Later Life: The Hiroshima-Nagasaki Atomic Bomb Survivor Study.

Publication ,  Journal Article
Itakura, K; Takahashi, I; Nakashima, E; Yanagi, M; Kawasaki, R; Neriishi, K; Wang, JJ; Wong, TY; Hida, A; Ohishi, W; Kiuchi, Y
Published in: Investigative ophthalmology & visual science
August 2015

To investigate the association between radiation exposure from the atomic bombings and the prevalence of age-related macular degeneration (AMD) among older residents of Hiroshima and Nagasaki.The Adult Health Study is a cohort study of atomic bomb survivors living in Hiroshima and Nagasaki, comprising 2153 participants who underwent examinations with retinal fundus photographs in 2006-2008. The radiation dose to the eye for the analysis was estimated with the revised dosimetry system (DS02). The retinal photographs were graded according to the Wisconsin Age-Related Maculopathy Grading System modified for nonstereoscopic retinal images. Early and late AMD were defined according to the type of lesion detected in the worse eye of the participants. Person-specific data were analyzed by using a logistic regression model to assess the association between radiation dose and AMD.Among the 1824 subjects with gradable retinal images (84.7% of the overall participants), the estimated eye dose was widely distributed, with a mean of 0.45 Gy and standard deviation of 0.74 Gy. The prevalence of early and late AMD was 10.5% and 0.3%, respectively. There were no significant associations between radiation dose and AMD, with each 1-Gy increase in exposure, adjusted odds ratio was 0.93 (95% confidence interval [CI], 0.75-1.15) for early AMD and 0.79 (95% CI, 0.21-2.94) for late AMD.No significant associations were found between atomic bomb irradiation early in life and the prevalence of early or late AMD later in life among Japanese atomic bomb survivors.

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Published In

Investigative ophthalmology & visual science

DOI

EISSN

1552-5783

ISSN

0146-0404

Publication Date

August 2015

Volume

56

Issue

9

Start / End Page

5401 / 5406

Related Subject Headings

  • Time Factors
  • Survivors
  • Retrospective Studies
  • Radioactive Hazard Release
  • Radiation Injuries
  • Prevalence
  • Ophthalmology & Optometry
  • Nuclear Weapons
  • Middle Aged
  • Male
 

Citation

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Itakura, K., Takahashi, I., Nakashima, E., Yanagi, M., Kawasaki, R., Neriishi, K., … Kiuchi, Y. (2015). Exposure to Atomic Bomb Radiation and Age-Related Macular Degeneration in Later Life: The Hiroshima-Nagasaki Atomic Bomb Survivor Study. Investigative Ophthalmology & Visual Science, 56(9), 5401–5406. https://doi.org/10.1167/iovs.15-16680
Itakura, Katsumasa, Ikuno Takahashi, Eiji Nakashima, Masahide Yanagi, Ryo Kawasaki, Kazuo Neriishi, Jie Jin Wang, et al. “Exposure to Atomic Bomb Radiation and Age-Related Macular Degeneration in Later Life: The Hiroshima-Nagasaki Atomic Bomb Survivor Study.Investigative Ophthalmology & Visual Science 56, no. 9 (August 2015): 5401–6. https://doi.org/10.1167/iovs.15-16680.
Itakura K, Takahashi I, Nakashima E, Yanagi M, Kawasaki R, Neriishi K, et al. Exposure to Atomic Bomb Radiation and Age-Related Macular Degeneration in Later Life: The Hiroshima-Nagasaki Atomic Bomb Survivor Study. Investigative ophthalmology & visual science. 2015 Aug;56(9):5401–6.
Itakura, Katsumasa, et al. “Exposure to Atomic Bomb Radiation and Age-Related Macular Degeneration in Later Life: The Hiroshima-Nagasaki Atomic Bomb Survivor Study.Investigative Ophthalmology & Visual Science, vol. 56, no. 9, Aug. 2015, pp. 5401–06. Epmc, doi:10.1167/iovs.15-16680.
Itakura K, Takahashi I, Nakashima E, Yanagi M, Kawasaki R, Neriishi K, Wang JJ, Wong TY, Hida A, Ohishi W, Kiuchi Y. Exposure to Atomic Bomb Radiation and Age-Related Macular Degeneration in Later Life: The Hiroshima-Nagasaki Atomic Bomb Survivor Study. Investigative ophthalmology & visual science. 2015 Aug;56(9):5401–5406.

Published In

Investigative ophthalmology & visual science

DOI

EISSN

1552-5783

ISSN

0146-0404

Publication Date

August 2015

Volume

56

Issue

9

Start / End Page

5401 / 5406

Related Subject Headings

  • Time Factors
  • Survivors
  • Retrospective Studies
  • Radioactive Hazard Release
  • Radiation Injuries
  • Prevalence
  • Ophthalmology & Optometry
  • Nuclear Weapons
  • Middle Aged
  • Male