Skip to main content

A nationwide cohort study of cigarette smoking and risk of neovascular age-related macular degeneration in East Asian men.

Publication ,  Journal Article
Rim, TH; Cheng, C-Y; Kim, DW; Kim, SS; Wong, TY
Published in: Br J Ophthalmol
October 2017

BACKGROUND: Few longitudinal studies have evaluated the relationship between cigarette smoking and risk of neovascular age-related macular degeneration (AMD) among Asian populations. This study aimed to prospectively evaluate the association between cigarette smoking and risk of neovascular AMD among Korean men. METHODS: Men between the ages of 45 and 79 years included in the Korea National Health Insurance Service database from 2002 through 2013. We compared hazard ratios (HR) for neovascular AMD between 64 560 past/current and 64 560 never smokers by 1:1 propensity-matched analysis and 85 267 past/current and 72 347 never smokers by unmatched cohort and propensity-adjusted analysis. RESULTS: The risk of neovascular AMD among past/current smokers was 50% higher than that among never smokers (propensity-adjusted whole cohort analysis: HR, 1.48; 95% CI 1.22 to 1.79; propensity-matched analysis: HR, 1.50; 95% CI 1.22 to 1.84), with the risk more pronounced among current than past smokers (current vs past smokers: propensity-adjusted whole cohort analysis, HR, 1.66; 95% CI 1.35 to 2.04 vs HR, 1.15, 95% CI 0.87 to 1.52; propensity-matched analysis, HR, 1.65; 95% CI 1.32 to 2.05 vs HR, 1.21; 95% CI 0.90 to 1.63). Duration of smoking and daily cigarette consumption was associated with the incidence of neovascular AMD in a dose-dependent manner (p<0.001 for trend). CONCLUSIONS: Cigarette smoking is associated with a strong risk of neovascular AMD among Korean men. These data highlight the public health impact of smoking on blindness in Asia.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

October 2017

Volume

101

Issue

10

Start / End Page

1367 / 1373

Location

England

Related Subject Headings

  • Smoking
  • Risk Factors
  • Republic of Korea
  • Prospective Studies
  • Proportional Hazards Models
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Degeneration
  • Incidence
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rim, T. H., Cheng, C.-Y., Kim, D. W., Kim, S. S., & Wong, T. Y. (2017). A nationwide cohort study of cigarette smoking and risk of neovascular age-related macular degeneration in East Asian men. Br J Ophthalmol, 101(10), 1367–1373. https://doi.org/10.1136/bjophthalmol-2016-309952
Rim, Tyler Hyungtaek, Ching-Yu Cheng, Dong Wook Kim, Sung Soo Kim, and Tien Y. Wong. “A nationwide cohort study of cigarette smoking and risk of neovascular age-related macular degeneration in East Asian men.Br J Ophthalmol 101, no. 10 (October 2017): 1367–73. https://doi.org/10.1136/bjophthalmol-2016-309952.
Rim TH, Cheng C-Y, Kim DW, Kim SS, Wong TY. A nationwide cohort study of cigarette smoking and risk of neovascular age-related macular degeneration in East Asian men. Br J Ophthalmol. 2017 Oct;101(10):1367–73.
Rim, Tyler Hyungtaek, et al. “A nationwide cohort study of cigarette smoking and risk of neovascular age-related macular degeneration in East Asian men.Br J Ophthalmol, vol. 101, no. 10, Oct. 2017, pp. 1367–73. Pubmed, doi:10.1136/bjophthalmol-2016-309952.
Rim TH, Cheng C-Y, Kim DW, Kim SS, Wong TY. A nationwide cohort study of cigarette smoking and risk of neovascular age-related macular degeneration in East Asian men. Br J Ophthalmol. 2017 Oct;101(10):1367–1373.

Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

October 2017

Volume

101

Issue

10

Start / End Page

1367 / 1373

Location

England

Related Subject Headings

  • Smoking
  • Risk Factors
  • Republic of Korea
  • Prospective Studies
  • Proportional Hazards Models
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Macular Degeneration
  • Incidence