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Emerging Therapies for Sensorineural Hearing Loss.

Publication ,  Journal Article
Crowson, MG; Hertzano, R; Tucci, DL
Published in: Otol Neurotol
July 2017

OBJECTIVE: To critically review and evaluate the proposed mechanisms and documented results of the therapeutics currently in active clinical drug trials for the treatment of sensorineural hearing loss. DATA SOURCES: US National Institutes of Health (NIH) Clinical Trials registry, MEDLINE/PubMed. STUDY SELECTION & DATA EXTRACTION: A review of the NIH Clinical Trials registry identified candidate hearing loss therapies, and supporting publications were acquired from MEDLINE/PubMed. Proof-of-concept, therapeutic mechanisms, and clinical outcomes were critically appraised. DATA SYNTHESIS: Twenty-two active clinical drug trials registered in the United States were identified, and six potentially therapeutic molecules were reviewed. Of the six molecules reviewed, four comprised mechanisms pertaining to mitigating oxidative stress pathways that presumably lead to inner ear cell death. One remaining therapy sought to manipulate the cell death cascade, and the last remaining therapy was a novel cell replacement therapy approach to introduce a transcription factor that promotes hair cell regeneration. CONCLUSION: A common theme in recent clinical trials registered in the United States appears to be the targeting of cell death pathways and influence of oxidant stressors on cochlear sensory neuroepithelium. In addition, a virus-delivered cell replacement therapy would be the first of its kind should it prove safe and efficacious. Significant challenges for bringing these bench-to-bedside therapies to market remain. It is never assured that results in non-human animal models translate to effective therapies in the setting of human biology. Moreover, as additional processes are described in association with hearing loss, such as an immune response and loss of synaptic contacts, additional pathways for targeting become available.

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Published In

Otol Neurotol

DOI

EISSN

1537-4505

Publication Date

July 2017

Volume

38

Issue

6

Start / End Page

792 / 803

Location

United States

Related Subject Headings

  • Otorhinolaryngology
  • Otolaryngology
  • Humans
  • Hearing Loss, Sensorineural
  • Animals
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
  • 0608 Zoology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Crowson, M. G., Hertzano, R., & Tucci, D. L. (2017). Emerging Therapies for Sensorineural Hearing Loss. Otol Neurotol, 38(6), 792–803. https://doi.org/10.1097/MAO.0000000000001427
Crowson, Matthew Gordon, Ronna Hertzano, and Debara L. Tucci. “Emerging Therapies for Sensorineural Hearing Loss.Otol Neurotol 38, no. 6 (July 2017): 792–803. https://doi.org/10.1097/MAO.0000000000001427.
Crowson MG, Hertzano R, Tucci DL. Emerging Therapies for Sensorineural Hearing Loss. Otol Neurotol. 2017 Jul;38(6):792–803.
Crowson, Matthew Gordon, et al. “Emerging Therapies for Sensorineural Hearing Loss.Otol Neurotol, vol. 38, no. 6, July 2017, pp. 792–803. Pubmed, doi:10.1097/MAO.0000000000001427.
Crowson MG, Hertzano R, Tucci DL. Emerging Therapies for Sensorineural Hearing Loss. Otol Neurotol. 2017 Jul;38(6):792–803.

Published In

Otol Neurotol

DOI

EISSN

1537-4505

Publication Date

July 2017

Volume

38

Issue

6

Start / End Page

792 / 803

Location

United States

Related Subject Headings

  • Otorhinolaryngology
  • Otolaryngology
  • Humans
  • Hearing Loss, Sensorineural
  • Animals
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
  • 0608 Zoology