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Sleep and metabolism: role of hypothalamic neuronal circuitry.

Publication ,  Journal Article
Rolls, A; Schaich Borg, J; de Lecea, L
Published in: Best practice & research. Clinical endocrinology & metabolism
October 2010

Sleep and metabolism are intertwined physiologically and behaviorally, but the neural systems underlying their coordination are still poorly understood. The hypothalamus is likely to play a major role in the regulation sleep, metabolism, and their interaction. And increasing evidence suggests that hypocretin cells in the lateral hypothalamus may provide particularly important contributions. Here we review: 1) direct interactions between biological arousal and metabolic systems in the hypothalamus, and 2) indirect interactions between these two systems mediated by stress or reward, emphasizing the role of hypocretins. An increased understanding of the mechanisms underlying these interactions may provide novel approaches for the treatment of patients with sleep disorders and obesity, as well as suggest new therapeutic strategies for symptoms of aging, stress, or addiction.

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Published In

Best practice & research. Clinical endocrinology & metabolism

DOI

EISSN

1878-1594

ISSN

1521-690X

Publication Date

October 2010

Volume

24

Issue

5

Start / End Page

817 / 828

Related Subject Headings

  • Stress, Physiological
  • Sleep
  • Reward
  • Nerve Net
  • Models, Biological
  • Metabolism
  • Metabolic Networks and Pathways
  • Hypothalamus
  • Humans
  • Feeding Behavior
 

Citation

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Rolls, A., Schaich Borg, J., & de Lecea, L. (2010). Sleep and metabolism: role of hypothalamic neuronal circuitry. Best Practice & Research. Clinical Endocrinology & Metabolism, 24(5), 817–828. https://doi.org/10.1016/j.beem.2010.08.002
Rolls, Asya, Jana Schaich Borg, and Luis de Lecea. “Sleep and metabolism: role of hypothalamic neuronal circuitry.Best Practice & Research. Clinical Endocrinology & Metabolism 24, no. 5 (October 2010): 817–28. https://doi.org/10.1016/j.beem.2010.08.002.
Rolls A, Schaich Borg J, de Lecea L. Sleep and metabolism: role of hypothalamic neuronal circuitry. Best practice & research Clinical endocrinology & metabolism. 2010 Oct;24(5):817–28.
Rolls, Asya, et al. “Sleep and metabolism: role of hypothalamic neuronal circuitry.Best Practice & Research. Clinical Endocrinology & Metabolism, vol. 24, no. 5, Oct. 2010, pp. 817–28. Epmc, doi:10.1016/j.beem.2010.08.002.
Rolls A, Schaich Borg J, de Lecea L. Sleep and metabolism: role of hypothalamic neuronal circuitry. Best practice & research Clinical endocrinology & metabolism. 2010 Oct;24(5):817–828.

Published In

Best practice & research. Clinical endocrinology & metabolism

DOI

EISSN

1878-1594

ISSN

1521-690X

Publication Date

October 2010

Volume

24

Issue

5

Start / End Page

817 / 828

Related Subject Headings

  • Stress, Physiological
  • Sleep
  • Reward
  • Nerve Net
  • Models, Biological
  • Metabolism
  • Metabolic Networks and Pathways
  • Hypothalamus
  • Humans
  • Feeding Behavior