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ICG angiography predicts burn scarring within 48 h of injury in a porcine vertical progression burn model.

Publication ,  Journal Article
Fourman, MS; McKenna, P; Phillips, BT; Crawford, L; Romanelli, F; Lin, F; McClain, SA; Khan, SU; Dagum, AB; Singer, AJ; Clark, RAF
Published in: Burns
August 2015

The current standard of care in determining the need to excise and graft a burn remains with the burn surgeon, whose clinical judgment is often variable. Prior work suggests that minimally invasive perfusion technologies are useful in burn prognostication. Here we test the predictive capabilities of Laser Doppler Imaging (LDI) and indocyanine green dye (ICG) angiography in the prediction of burn scarring 28 days after injury using a previously validated porcine burn model that shows vertical progression injury. Twelve female Yorkshire swine were burned using a 2.5 × 2.5 cm metal bar at variable temperature and application times to create distinct burn depths. Six animals (48 injuries total) each were analyzed with LDI or ICG angiography at 1, 24, 48, and 72 h following injury. A linear regression was then performed correlating perfusion measurements against wound contraction at 28 days after injury. ICG angiography showed a peak linear correlate (r(2)) of .63 (95% CI .34 to .92) at 48 h after burn. This was significantly different from the LDI linear regression (p < .05), which was measured at r(2) of .20 (95% CI .02 to .39). ICG angiography linear regression was superior to LDI at all timepoints. Findings suggest that ICG angiography may have significant potential in the prediction of long-term burn outcomes.

Duke Scholars

Published In

Burns

DOI

EISSN

1879-1409

Publication Date

August 2015

Volume

41

Issue

5

Start / End Page

1043 / 1048

Location

Netherlands

Related Subject Headings

  • Swine
  • Sus scrofa
  • Skin
  • Regional Blood Flow
  • Pilot Projects
  • Optical Imaging
  • Linear Models
  • Laser-Doppler Flowmetry
  • Indocyanine Green
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fourman, M. S., McKenna, P., Phillips, B. T., Crawford, L., Romanelli, F., Lin, F., … Clark, R. A. F. (2015). ICG angiography predicts burn scarring within 48 h of injury in a porcine vertical progression burn model. Burns, 41(5), 1043–1048. https://doi.org/10.1016/j.burns.2014.11.001
Fourman, Mitchell S., Peter McKenna, Brett T. Phillips, Laurie Crawford, Filippo Romanelli, Fubao Lin, Steve A. McClain, et al. “ICG angiography predicts burn scarring within 48 h of injury in a porcine vertical progression burn model.Burns 41, no. 5 (August 2015): 1043–48. https://doi.org/10.1016/j.burns.2014.11.001.
Fourman MS, McKenna P, Phillips BT, Crawford L, Romanelli F, Lin F, et al. ICG angiography predicts burn scarring within 48 h of injury in a porcine vertical progression burn model. Burns. 2015 Aug;41(5):1043–8.
Fourman, Mitchell S., et al. “ICG angiography predicts burn scarring within 48 h of injury in a porcine vertical progression burn model.Burns, vol. 41, no. 5, Aug. 2015, pp. 1043–48. Pubmed, doi:10.1016/j.burns.2014.11.001.
Fourman MS, McKenna P, Phillips BT, Crawford L, Romanelli F, Lin F, McClain SA, Khan SU, Dagum AB, Singer AJ, Clark RAF. ICG angiography predicts burn scarring within 48 h of injury in a porcine vertical progression burn model. Burns. 2015 Aug;41(5):1043–1048.
Journal cover image

Published In

Burns

DOI

EISSN

1879-1409

Publication Date

August 2015

Volume

41

Issue

5

Start / End Page

1043 / 1048

Location

Netherlands

Related Subject Headings

  • Swine
  • Sus scrofa
  • Skin
  • Regional Blood Flow
  • Pilot Projects
  • Optical Imaging
  • Linear Models
  • Laser-Doppler Flowmetry
  • Indocyanine Green
  • Female