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Comparison of Corneal Biomechanical Properties between Indian and Chinese Adults.

Publication ,  Journal Article
Chua, J; Nongpiur, ME; Zhao, W; Tham, YC; Gupta, P; Sabanayagam, C; Aung, T; Wong, TY; Cheng, C-Y
Published in: Ophthalmology
September 2017

PURPOSE: To investigate the difference in corneal hysteresis (CH) and corneal resistance factor (CRF) between Indian and Chinese populations. DESIGN: Population-based cross-sectional study. PARTICIPANTS: Three hundred eighty-two Singaporean Indian persons and 764 Singaporean Chinese 50 years of age or older were included from the Singapore Indian Eye Study and Singapore Chinese Eye Study, respectively. METHODS: Participants underwent standardized systemic and ocular examinations and interviewer-administered questionnaires for risk factor assessment. The CH and CRF were measured with the Ocular Response Analyzer (Reichert Ophthalmic Instruments, Buffalo, NY). Information on genetic ancestry was derived using principal component analysis. Linear regression models were used to investigate the association of CH and CRF with potential risk factors. MAIN OUTCOME MEASURES: Corneal hysteresis and CRF. RESULTS: After excluding participants with a history of intraocular surgery, a diagnosis of glaucoma suspect or glaucoma, refractive surgery, or presence of corneal abnormalities, CH and CRF readings were available for 382 Indian persons. For each Indian participant, 2 Chinese participants were selected and matched for age and gender (n = 764). There were no differences in the clinical measurements of CH (10.6±1.6 mmHg; P = 0.670) or CRF (10.3±1.7 mmHg; P = 0.103) between the ethnic groups. However, after adjusting for covariates, Indian persons had, on average, 0.18-mmHg higher CH levels than in Chinese (95% confidence interval [CI], 0.02-0.38; P = 0.031). Consistently, CH level was correlated significantly with genetic ancestry in the Southeast Asian population. Corneal resistance factor level was not associated independently with self-reported ethnicity (95% CI, -0.10 to 0.29; P = 0.335). CONCLUSIONS: Chinese have lower CH than Indian persons, and this disparity may reflect biomechanical differences of the cornea.

Duke Scholars

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Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

September 2017

Volume

124

Issue

9

Start / End Page

1271 / 1279

Location

United States

Related Subject Headings

  • Tonometry, Ocular
  • Surveys and Questionnaires
  • Singapore
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Intraocular Pressure
  • India
 

Citation

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Chicago
ICMJE
MLA
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Chua, J., Nongpiur, M. E., Zhao, W., Tham, Y. C., Gupta, P., Sabanayagam, C., … Cheng, C.-Y. (2017). Comparison of Corneal Biomechanical Properties between Indian and Chinese Adults. Ophthalmology, 124(9), 1271–1279. https://doi.org/10.1016/j.ophtha.2017.03.055
Chua, Jacqueline, Monisha E. Nongpiur, Wanting Zhao, Yih Chung Tham, Preeti Gupta, Charumathi Sabanayagam, Tin Aung, Tien Yin Wong, and Ching-Yu Cheng. “Comparison of Corneal Biomechanical Properties between Indian and Chinese Adults.Ophthalmology 124, no. 9 (September 2017): 1271–79. https://doi.org/10.1016/j.ophtha.2017.03.055.
Chua J, Nongpiur ME, Zhao W, Tham YC, Gupta P, Sabanayagam C, et al. Comparison of Corneal Biomechanical Properties between Indian and Chinese Adults. Ophthalmology. 2017 Sep;124(9):1271–9.
Chua, Jacqueline, et al. “Comparison of Corneal Biomechanical Properties between Indian and Chinese Adults.Ophthalmology, vol. 124, no. 9, Sept. 2017, pp. 1271–79. Pubmed, doi:10.1016/j.ophtha.2017.03.055.
Chua J, Nongpiur ME, Zhao W, Tham YC, Gupta P, Sabanayagam C, Aung T, Wong TY, Cheng C-Y. Comparison of Corneal Biomechanical Properties between Indian and Chinese Adults. Ophthalmology. 2017 Sep;124(9):1271–1279.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

September 2017

Volume

124

Issue

9

Start / End Page

1271 / 1279

Location

United States

Related Subject Headings

  • Tonometry, Ocular
  • Surveys and Questionnaires
  • Singapore
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Intraocular Pressure
  • India