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Perceptions of Statin Discontinuation among Patients with Life-Limiting Illness.

Publication ,  Journal Article
Tjia, J; Kutner, JS; Ritchie, CS; Blatchford, PJ; Bennett Kendrick, RE; Prince-Paul, M; Somers, TJ; McPherson, ML; Sloan, JA; Abernethy, AP ...
Published in: J Palliat Med
October 2017

BACKGROUND: Optimal management of chronic medications for patients with life-limiting illness is uncertain. Medication deprescribing may improve outcomes in this population, but patient concerns regarding deprescribing are unclear. OBJECTIVE: The aim of this study was to quantify the perceived benefits and concerns of statin discontinuation among patients with life-limiting illness. DESIGN: Baseline data from a multicenter, pragmatic clinical trial of statin discontinuation were used. SETTING/SUBJECTS: Cognitively intact participants with a life expectancy of 1-12 months receiving statin medications for primary or secondary prevention were enrolled. MEASUREMENTS: Responses to a 9-item questionnaire addressing patient concerns about discontinuing statins were collected. We used Pearson chi-square tests to compare responses by primary life-limiting diagnosis (cancer, cardiovascular disease, other). RESULTS: Of 297 eligible participants, 58% had cancer, 8% had cardiovascular disease, and 30% other primary diagnoses. Mean (standard deviation) age was 72 (11) years. Fewer than 5% of participants expressed concern that statin deprescribing indicated physician abandonment. About one in five participants reported being told to take statins for the rest of their life (18%) or feeling that discontinuation represented prior wasted effort (18%). Many participants reported benefits of stopping statins, including spending less money on medications (63%), potentially stopping other medications (34%), and having a better quality of life (25%). More participants with cardiovascular disease as a primary diagnosis perceived that quality-of-life benefits related to statin discontinuation (52%) than participants with cancer (27%) or noncardiovascular disease diagnoses (27%) [p = 0.034]. CONCLUSION: Few participants expressed concerns about discontinuing statins; many perceived potential benefits. Cardiovascular disease patients perceived greater potential positive impact from statin discontinuation.

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Published In

J Palliat Med

DOI

EISSN

1557-7740

Publication Date

October 2017

Volume

20

Issue

10

Start / End Page

1098 / 1103

Location

United States

Related Subject Headings

  • Withholding Treatment
  • Quality of Life
  • Patient Preference
  • Neoplasms
  • Middle Aged
  • Male
  • Life Expectancy
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Gerontology
 

Citation

APA
Chicago
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Tjia, J., Kutner, J. S., Ritchie, C. S., Blatchford, P. J., Bennett Kendrick, R. E., Prince-Paul, M., … Furuno, J. P. (2017). Perceptions of Statin Discontinuation among Patients with Life-Limiting Illness. J Palliat Med, 20(10), 1098–1103. https://doi.org/10.1089/jpm.2016.0489
Tjia, Jennifer, Jean S. Kutner, Christine S. Ritchie, Patrick J. Blatchford, Rachael E. Bennett Kendrick, Maryjo Prince-Paul, Tamara J. Somers, et al. “Perceptions of Statin Discontinuation among Patients with Life-Limiting Illness.J Palliat Med 20, no. 10 (October 2017): 1098–1103. https://doi.org/10.1089/jpm.2016.0489.
Tjia J, Kutner JS, Ritchie CS, Blatchford PJ, Bennett Kendrick RE, Prince-Paul M, et al. Perceptions of Statin Discontinuation among Patients with Life-Limiting Illness. J Palliat Med. 2017 Oct;20(10):1098–103.
Tjia, Jennifer, et al. “Perceptions of Statin Discontinuation among Patients with Life-Limiting Illness.J Palliat Med, vol. 20, no. 10, Oct. 2017, pp. 1098–103. Pubmed, doi:10.1089/jpm.2016.0489.
Tjia J, Kutner JS, Ritchie CS, Blatchford PJ, Bennett Kendrick RE, Prince-Paul M, Somers TJ, McPherson ML, Sloan JA, Abernethy AP, Furuno JP. Perceptions of Statin Discontinuation among Patients with Life-Limiting Illness. J Palliat Med. 2017 Oct;20(10):1098–1103.
Journal cover image

Published In

J Palliat Med

DOI

EISSN

1557-7740

Publication Date

October 2017

Volume

20

Issue

10

Start / End Page

1098 / 1103

Location

United States

Related Subject Headings

  • Withholding Treatment
  • Quality of Life
  • Patient Preference
  • Neoplasms
  • Middle Aged
  • Male
  • Life Expectancy
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • Gerontology