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Rotational manipulation of single cells and organisms using acoustic waves

Publication ,  Journal Article
Ahmed, D; Ozcelik, A; Bojanala, N; Nama, N; Upadhyay, A; Chen, Y; Hanna-Rose, W; Huang, TJ
Published in: Nature Communications
March 23, 2016

The precise rotational manipulation of single cells or organisms is invaluable to many applications in biology, chemistry, physics and medicine. In this article, we describe an acoustic-based, on-chip manipulation method that can rotate single microparticles, cells and organisms. To achieve this, we trapped microbubbles within predefined sidewall microcavities inside a microchannel. In an acoustic field, trapped microbubbles were driven into oscillatory motion generating steady microvortices which were utilized to precisely rotate colloids, cells and entire organisms (that is, ). We have tested the capabilities of our method by analysing reproductive system pathologies and nervous system morphology in . Using our device, we revealed the underlying abnormal cell fusion causing defective vulval morphology in mutant worms. Our acoustofluidic rotational manipulation (ARM) technique is an easy-to-use, compact, and biocompatible method, permitting rotation regardless of optical, magnetic or electrical properties of the sample under investigation.

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Published In

Nature Communications

DOI

EISSN

2041-1723

Publication Date

March 23, 2016

Volume

7

Issue

1

Publisher

Springer Science and Business Media LLC
 

Citation

APA
Chicago
ICMJE
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Ahmed, D., Ozcelik, A., Bojanala, N., Nama, N., Upadhyay, A., Chen, Y., … Huang, T. J. (2016). Rotational manipulation of single cells and organisms using acoustic waves. Nature Communications, 7(1). https://doi.org/10.1038/ncomms11085
Ahmed, Daniel, Adem Ozcelik, Nagagireesh Bojanala, Nitesh Nama, Awani Upadhyay, Yuchao Chen, Wendy Hanna-Rose, and Tony Jun Huang. “Rotational manipulation of single cells and organisms using acoustic waves.” Nature Communications 7, no. 1 (March 23, 2016). https://doi.org/10.1038/ncomms11085.
Ahmed D, Ozcelik A, Bojanala N, Nama N, Upadhyay A, Chen Y, et al. Rotational manipulation of single cells and organisms using acoustic waves. Nature Communications. 2016 Mar 23;7(1).
Ahmed, Daniel, et al. “Rotational manipulation of single cells and organisms using acoustic waves.” Nature Communications, vol. 7, no. 1, Springer Science and Business Media LLC, Mar. 2016. Crossref, doi:10.1038/ncomms11085.
Ahmed D, Ozcelik A, Bojanala N, Nama N, Upadhyay A, Chen Y, Hanna-Rose W, Huang TJ. Rotational manipulation of single cells and organisms using acoustic waves. Nature Communications. Springer Science and Business Media LLC; 2016 Mar 23;7(1).

Published In

Nature Communications

DOI

EISSN

2041-1723

Publication Date

March 23, 2016

Volume

7

Issue

1

Publisher

Springer Science and Business Media LLC